Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0002364
UniProt IDQ6PGN9
Primary gene name(s)PSRC1
Synonym gene name(s)DDA3
Protein nameProline/serine-rich coiled-coil protein 1
Protein functionRequired for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores. Recruits KIF2A and ANKRD53 to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression. {ECO:0000269|PubMed:18411309, ECO:0000269|PubMed:19738423, ECO:0000269|PubMed:26820536}.
Subcellular locationCytoplasm. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Detected at the mitotic spindle and spindle poles. Diffusely distributed throughout the cell during interphase.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q6PGN9
Gene Ontology
(Biological Process)
Complete annatation
cell division [GO:0051301];
microtubule bundle formation [GO:0001578];
mitotic metaphase plate congression [GO:0007080];
negative regulation of cell growth [GO:0030308];
positive regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045737];
positive regulation of microtubule polymerization [GO:0031116];
positive regulation of transcription, DNA-templated [GO:0045893];
regulation of mitotic spindle organization [GO:0060236]
Gene Ontology
(Molecular Function)
Complete annatation
microtubule binding [GO:0008017]
Gene Ontology
(Cellular Component)
Complete annatation
cytoplasm [GO:0005737];
cytosol [GO:0005829];
microtubule cytoskeleton [GO:0015630];
midbody [GO:0030496];
spindle [GO:0005819];
spindle pole [GO:0000922]
Protein-protein interaction124224
Phylogenetic treeQ6PGN9
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-2.015870951159490.0001124186705864230.000535516499076664
AZA vs. DISU-0.7303063881048750.05066929617887630.504387225901706
AZA vs. IL7-0.01335988934677250.9709311263600220.999311006273513
AZA vs. SAHA0.9450345215552550.03269179269684860.209255236990359
DISU vs. CD31.26809644622980.007714506542450980.0233510987190575
DISU vs. IL70.7046146741390310.01952752252239120.17418781184914
DISU vs. SAHA1.675069577071991.24048321239467e-050.000772533987355376
DMSO vs. AZA-0.2196493439016690.6181212130410641
DMSO vs. CD31.787614188597740.0008308882845683430.00291033062241853
DMSO vs. DISU0.5074627478318450.1909883391610840.707325086600012
DMSO vs. IL70.2139815329491130.576158895116930.905471261013899
DMSO vs. SAHA1.159480414213690.01147870233228410.0985729474927941
HIV vs. Mock in Activationunknownunknownunknown
HIV vs. Mock in Latency0.3276026132690550.2781491700073590.999834320637052
IL7 vs. CD32.006347832174562.48688084749649e-050.000172979949304636
SAHA vs. CD32.923745107149182.64306579955687e-072.48788267328682e-06
SAHA vs. IL70.959802013543140.01308129201154240.0756013106258692
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) FALSE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.393838 0.0107117
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
0.951 1.121 1.188 1.225 1.013
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
201896_s_at 1.4 No upregulated in CD8+ cells

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
not found