Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0002333
UniProt IDQ92786
Primary gene name(s)PROX1
Synonym gene name(s)unknown
Protein nameProspero homeobox protein 1
Protein functionTranscription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. Plays a critical role in embryonic development and functions as a key regulatory protein in neurogenesis and the development of the heart, eye lens, liver, pancreas and the lymphatic system. Involved in the regulation of the circadian rhythm. Represses: transcription of the retinoid-related orphan receptor RORG, transcriptional activator activity of RORA and RORG and the expression of RORA/G-target genes including core clock components: ARNTL/BMAL1, NPAS2 and CRY1 and metabolic genes: AVPR1A and ELOVL3. {ECO:0000269|PubMed:23723244, ECO:0000303|PubMed:22733308}.
Subcellular locationNucleus {ECO:0000250|UniProtKB:P48437}. Note=RORG promotes its nuclear localization. {ECO:0000250|UniProtKB:P48437}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q92786
Gene Ontology
(Biological Process)
Complete annatation
acinar cell differentiation [GO:0090425];
aorta smooth muscle tissue morphogenesis [GO:0060414];
atrial cardiac muscle tissue morphogenesis [GO:0055009];
brain development [GO:0007420];
branching involved in pancreas morphogenesis [GO:0061114];
cardiac muscle cell differentiation [GO:0055007];
cell fate determination [GO:0001709];
cerebellar granule cell differentiation [GO:0021707];
circadian rhythm [GO:0007623];
dentate gyrus development [GO:0021542];
dorsal spinal cord development [GO:0021516];
embryonic retina morphogenesis in camera-type eye [GO:0060059];
endocardium formation [GO:0060214];
hepatocyte cell migration [GO:0002194];
hepatocyte differentiation [GO:0070365];
hepatocyte proliferation [GO:0072574];
kidney development [GO:0001822];
lens development in camera-type eye [GO:0002088];
lens fiber cell morphogenesis [GO:0070309];
liver development [GO:0001889];
lung development [GO:0030324];
lymphangiogenesis [GO:0001946];
lymphatic endothelial cell differentiation [GO:0060836];
negative regulation of bile acid biosynthetic process [GO:0070858];
negative regulation of cell proliferation [GO:0008285];
negative regulation of sequence-specific DNA binding transcription factor activity [GO:0043433];
negative regulation of transcription, DNA-templated [GO:0045892];
negative regulation of transcription from RNA polymerase II promoter [GO:0000122];
negative regulation of viral genome replication [GO:0045071];
neural tube development [GO:0021915];
neuronal stem cell population maintenance [GO:0097150];
neuron differentiation [GO:0030182];
olfactory placode formation [GO:0030910];
optic placode formation involved in camera-type eye formation [GO:0046619];
otic placode formation [GO:0043049];
pancreas development [GO:0031016];
positive regulation of cell cycle [GO:0045787];
positive regulation of cell cycle checkpoint [GO:1901978];
positive regulation of cell proliferation [GO:0008284];
positive regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045737];
positive regulation of endothelial cell migration [GO:0010595];
positive regulation of endothelial cell proliferation [GO:0001938];
positive regulation of forebrain neuron differentiation [GO:2000979];
positive regulation of heart growth [GO:0060421];
positive regulation of neural precursor cell proliferation [GO:2000179];
positive regulation of sarcomere organization [GO:0060298];
positive regulation of transcription, DNA-templated [GO:0045893];
positive regulation of transcription from RNA polymerase II promoter [GO:0045944];
regulation of circadian rhythm [GO:0042752];
regulation of gene expression [GO:0010468];
regulation of transcription involved in lymphatic endothelial cell fate commitment [GO:0060849];
response to nutrient levels [GO:0031667];
retina morphogenesis in camera-type eye [GO:0060042];
skeletal muscle thin filament assembly [GO:0030240];
transcription, DNA-templated [GO:0006351];
venous blood vessel morphogenesis [GO:0048845];
ventricular cardiac muscle tissue morphogenesis [GO:0055010];
ventricular cardiac myofibril assembly [GO:0055005];
ventricular septum morphogenesis [GO:0060412]
Gene Ontology
(Molecular Function)
Complete annatation
core promoter sequence-specific DNA binding [GO:0001046];
DBD domain binding [GO:0050692];
DNA binding [GO:0003677];
LBD domain binding [GO:0050693];
ligand-dependent nuclear receptor binding [GO:0016922];
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding [GO:0001078];
transcription corepressor activity [GO:0003714];
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding [GO:0003705];
transcription factor activity, sequence-specific DNA binding [GO:0003700];
transcription regulatory region DNA binding [GO:0044212]
Gene Ontology
(Cellular Component)
Complete annatation
cytoplasm [GO:0005737];
nucleus [GO:0005634]
Protein-protein interaction111613
Phylogenetic treeQ92786
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
      unknown
Brass et al., Science, 2008
      unknown
Smith et al., J. Immunol, 2010
      unknown
Interferon-stimulated
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model


DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3unknownunknownunknown
AZA vs. DISUunknownunknownunknown
AZA vs. IL7unknownunknownunknown
AZA vs. SAHAunknownunknownunknown
DISU vs. CD3unknownunknownunknown
DISU vs. IL7unknownunknownunknown
DISU vs. SAHAunknownunknownunknown
DMSO vs. AZAunknownunknownunknown
DMSO vs. CD3unknownunknownunknown
DMSO vs. DISUunknownunknownunknown
DMSO vs. IL7unknownunknownunknown
DMSO vs. SAHAunknownunknownunknown
HIV vs. Mock in Activationunknownunknownunknown
HIV vs. Mock in Latencyunknownunknownunknown
IL7 vs. CD3unknownunknownunknown
SAHA vs. CD3unknownunknownunknown
SAHA vs. IL7unknownunknownunknown
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) TRUE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
NOTEST 1.21181 1
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
2LMD NMR - A=575-737.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
HIV-1 virus replication enhanced by expression of human gene 19460752

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
not found
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