Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0002308
UniProt IDQ06830
Primary gene name(s)PRDX1
Synonym gene name(s)PAGA, PAGB, TDPX2
Protein namePeroxiredoxin-1
Protein functionInvolved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2O(2. Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation, By similarity. {ECO:0000250}.
Subcellular locationCytoplasm {ECO:0000269|PubMed:17081065}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q06830
Gene Ontology
(Biological Process)
Complete annatation
cell proliferation [GO:0008283];
cell redox homeostasis [GO:0045454];
erythrocyte homeostasis [GO:0034101];
hydrogen peroxide catabolic process [GO:0042744];
natural killer cell mediated cytotoxicity [GO:0042267];
regulation of NF-kappaB import into nucleus [GO:0042345];
regulation of stress-activated MAPK cascade [GO:0032872];
removal of superoxide radicals [GO:0019430];
response to reactive oxygen species [GO:0000302];
retina homeostasis [GO:0001895];
skeletal system development [GO:0001501]
Gene Ontology
(Molecular Function)
Complete annatation
peroxidase activity [GO:0004601];
poly(A RNA binding [GO:0044822];
thioredoxin peroxidase activity [GO:0008379]
Gene Ontology
(Cellular Component)
Complete annatation
cytoplasm [GO:0005737];
cytosol [GO:0005829];
extracellular exosome [GO:0070062];
extracellular space [GO:0005615];
melanosome [GO:0042470];
mitochondrion [GO:0005739];
myelin sheath [GO:0043209];
nucleus [GO:0005634]
Protein-protein interaction111089
Phylogenetic treeQ06830
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD32.231520987851786.72436550885891e-111.2137681071799e-09
AZA vs. DISU0.650578399493840.1139427817446070.666214285160747
AZA vs. IL70.3805100414026560.04770423502361310.644768550316037
AZA vs. SAHA-0.3734778422509780.1256478721582920.451126014972762
DISU vs. CD3-1.594999514843110.0001797130931295850.000947201106935444
DISU vs. IL7-0.2789920253570750.513814124966240.833989694649153
DISU vs. SAHA-1.021911868948420.01358281499065720.126638573484536
DMSO vs. AZA-0.01502028087076360.9283726682568691
DMSO vs. CD3-2.258914377949111.43316469802812e-112.58570373362798e-10
DMSO vs. DISU-0.6677549047382380.1068420461265540.581051936518753
DMSO vs. IL70.4028513975507450.0249344771002530.321809580752529
DMSO vs. SAHA-0.3646182668232490.121841968801910.415918530422103
HIV vs. Mock in Activation-0.2589506330447580.6769205776789010.999983755607037
HIV vs. Mock in Latency-0.06071729270540290.712746169234150.999834320637052
IL7 vs. CD3-1.843126245398522.68579321005546e-083.70723086585769e-07
SAHA vs. CD3-2.629290677454512.24775753565609e-126.4644477218201e-11
SAHA vs. IL7-0.7567190099080290.001972221876043510.0195073966925721
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) FALSE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.244147 0.0763893
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
0.121 0.005

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
1.019 1.081 1.163 1.213 1.048
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
208680_at 1.47 Yes upregulated in CD4+ cells
208680_at 1.5 Yes upregulated in CD8+ cells

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
2RII X-ray 2.6Å A/B=1-199.
3HY2 X-ray 2.1Å A/B=1-199.
4XCS X-ray 2.1Å A/B/C/D/E/F=1-199.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
retropepsin cleaves 22944692
Envelope surface glycoprotein gp120 upregulates 17676665

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04146 Peroxisome - Homo sapiens (human)