Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0002205
UniProt IDQ00722
Primary gene name(s)PLCB2
Synonym gene name(s)unknown
Protein name1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
Protein functionThe production of the second messenger molecules diacylglycerol, DAG and inositol 1,4,5-trisphosphate, IP3 is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
Subcellular locationunknown
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q00722
Gene Ontology
(Biological Process)
Complete annatation
activation of phospholipase C activity [GO:0007202];
inositol phosphate metabolic process [GO:0043647];
intracellular signal transduction [GO:0035556];
lipid catabolic process [GO:0016042];
phospholipid metabolic process [GO:0006644];
sensory perception of bitter taste [GO:0050913];
Wnt signaling pathway, calcium modulating pathway [GO:0007223]
Gene Ontology
(Molecular Function)
Complete annatation
calcium ion binding [GO:0005509];
phosphatidylinositol phospholipase C activity [GO:0004435];
phospholipase C activity [GO:0004629];
signal transducer activity [GO:0004871]
Gene Ontology
(Cellular Component)
Complete annatation
cytosol [GO:0005829]
Protein-protein interaction111346
Phylogenetic treeQ00722
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
      unknown
Brass et al., Science, 2008
      unknown
Smith et al., J. Immunol, 2010
      unknown
Interferon-stimulated
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model


DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-3.765692156177295.80841175157332e-097.21717905356249e-08
AZA vs. DISU-0.1460561441730360.5631462256140370.951925020821155
AZA vs. IL7-0.1371953815845330.5136977392261770.999311006273513
AZA vs. SAHA-0.8499357538989050.002888557288707740.0431537290089003
DISU vs. CD33.607538352108581.32876063485554e-081.98314235740717e-07
DISU vs. IL7-0.0009436910991795920.9970082625841350.999957156847617
DISU vs. SAHA-0.7009121221855860.01674237996681120.144185376274178
DMSO vs. AZA0.1416185740697290.3959790157021631
DMSO vs. CD33.896619945272911.01498731641669e-091.31138798643375e-08
DMSO vs. DISU0.2863122706338910.2403162115678230.757174432014865
DMSO vs. IL7-0.2716617485377650.1297850812569290.62814773342175
DMSO vs. SAHA-0.9964445262793889.69196315461218e-050.00344499001658397
HIV vs. Mock in Activation0.2831706856636740.8188028640796970.999983755607037
HIV vs. Mock in Latency0.1149449037935890.4846716497826310.999834320637052
IL7 vs. CD33.633166878483831.6888522913483e-082.42208093125527e-07
SAHA vs. CD32.893752244323887.43525556978764e-064.85903301980484e-05
SAHA vs. IL7-0.714746968881990.01297302346088640.0751269134265851
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) TRUE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.158437 0.3461
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
0.925 0.888 1.164 1.331 0.918
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
2FJU X-ray 2.2Å B=1-803.
2ZKM X-ray 1.6Å X=1-799.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Tat activates 7589147
9278385
9730685
10501179
10843712
12482669
Tat cooperates with 20336759
Envelope surface glycoprotein gp120 regulated by 18632858
20842205
Envelope surface glycoprotein gp120 inactivates 1979339

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa00562 Inositol phosphate metabolism - Homo sapiens (human)
hsa01100 Metabolic pathways - Homo sapiens (human)
hsa04015 Rap1 signaling pathway - Homo sapiens (human)
hsa04020 Calcium signaling pathway - Homo sapiens (human)
hsa04022 cGMP-PKG signaling pathway - Homo sapiens (human)
hsa04062 Chemokine signaling pathway - Homo sapiens (human)
hsa04070 Phosphatidylinositol signaling system - Homo sapiens (human)
hsa04071 Sphingolipid signaling pathway - Homo sapiens (human)
hsa04072 Phospholipase D signaling pathway - Homo sapiens (human)
hsa04261 Adrenergic signaling in cardiomyocytes - Homo sapiens (human)
hsa04270 Vascular smooth muscle contraction - Homo sapiens (human)
hsa04310 Wnt signaling pathway - Homo sapiens (human)
hsa04540 Gap junction - Homo sapiens (human)
hsa04611 Platelet activation - Homo sapiens (human)
hsa04621 NOD-like receptor signaling pathway - Homo sapiens (human)
hsa04713 Circadian entrainment - Homo sapiens (human)
hsa04720 Long-term potentiation - Homo sapiens (human)
hsa04723 Retrograde endocannabinoid signaling - Homo sapiens (human)
hsa04724 Glutamatergic synapse - Homo sapiens (human)
hsa04725 Cholinergic synapse - Homo sapiens (human)
hsa04726 Serotonergic synapse - Homo sapiens (human)
hsa04728 Dopaminergic synapse - Homo sapiens (human)
hsa04730 Long-term depression - Homo sapiens (human)
hsa04742 Taste transduction - Homo sapiens (human)
hsa04750 Inflammatory mediator regulation of TRP channels - Homo sapiens (human)
hsa04911 Insulin secretion - Homo sapiens (human)
hsa04912 GnRH signaling pathway - Homo sapiens (human)
hsa04915 Estrogen signaling pathway - Homo sapiens (human)
hsa04916 Melanogenesis - Homo sapiens (human)
hsa04918 Thyroid hormone synthesis - Homo sapiens (human)
hsa04919 Thyroid hormone signaling pathway - Homo sapiens (human)
hsa04921 Oxytocin signaling pathway - Homo sapiens (human)
hsa04922 Glucagon signaling pathway - Homo sapiens (human)
hsa04924 Renin secretion - Homo sapiens (human)
hsa04925 Aldosterone synthesis and secretion - Homo sapiens (human)
hsa04933 AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)
hsa04961 Endocrine and other factor-regulated calcium reabsorption - Homo sapiens (human)
hsa04970 Salivary secretion - Homo sapiens (human)
hsa04971 Gastric acid secretion - Homo sapiens (human)
hsa04972 Pancreatic secretion - Homo sapiens (human)
hsa04973 Carbohydrate digestion and absorption - Homo sapiens (human)
hsa05010 Alzheimer's disease - Homo sapiens (human)
hsa05016 Huntington's disease - Homo sapiens (human)
hsa05142 Chagas disease (American trypanosomiasis) - Homo sapiens (human)
hsa05143 African trypanosomiasis - Homo sapiens (human)
hsa05146 Amoebiasis - Homo sapiens (human)
hsa05200 Pathways in cancer - Homo sapiens (human)
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