Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0002155
UniProt IDP35232
Primary gene name(s)PHB
Synonym gene name(s)unknown
Protein nameProhibitin
Protein functionProhibitin inhibits DNA synthesis. It has a role in regulating proliferation. As yet it is unclear if the protein or the mRNA exhibits this effect. May play a role in regulating mitochondrial respiration activity and in aging. {ECO:0000269|PubMed:11302691}.
Subcellular locationMitochondrion inner membrane {ECO:0000250}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P35232
Gene Ontology
(Biological Process)
Complete annatation
cellular response to interleukin-6 [GO:0071354];
DNA biosynthetic process [GO:0071897];
histone deacetylation [GO:0016575];
mitochondrion organization [GO:0007005];
negative regulation of androgen receptor signaling pathway [GO:0060766];
negative regulation of cell growth [GO:0030308];
negative regulation of cell proliferation [GO:0008285];
negative regulation of ERK1 and ERK2 cascade [GO:0070373];
negative regulation of glucocorticoid receptor signaling pathway [GO:2000323];
negative regulation of protein catabolic process [GO:0042177];
negative regulation of transcription, DNA-templated [GO:0045892];
negative regulation of transcription by competitive promoter binding [GO:0010944];
negative regulation of transcription from RNA polymerase II promoter [GO:0000122];
osteoblast differentiation [GO:0001649];
positive regulation of cell death [GO:0010942];
positive regulation of complement activation [GO:0045917];
positive regulation of ERK1 and ERK2 cascade [GO:0070374];
positive regulation of gene expression [GO:0010628];
positive regulation of G-protein coupled receptor protein signaling pathway [GO:0045745];
positive regulation of transcription, DNA-templated [GO:0045893];
progesterone receptor signaling pathway [GO:0050847];
protein stabilization [GO:0050821];
regulation of apoptotic process [GO:0042981];
regulation of transcription, DNA-templated [GO:0006355];
signal transduction [GO:0007165]
Gene Ontology
(Molecular Function)
Complete annatation
complement component C3a binding [GO:0001850];
complement component C3b binding [GO:0001851];
enzyme binding [GO:0019899];
histone deacetylase binding [GO:0042826];
proteinase activated receptor binding [GO:0031871];
protein C-terminus binding [GO:0008022];
RNA polymerase II transcription factor activity, sequence-specific DNA binding [GO:0000981];
transcription regulatory region DNA binding [GO:0044212]
Gene Ontology
(Cellular Component)
Complete annatation
cell surface [GO:0009986];
cytoplasm [GO:0005737];
early endosome [GO:0005769];
extracellular exosome [GO:0070062];
integral component of plasma membrane [GO:0005887];
membrane [GO:0016020];
mitochondrial inner membrane [GO:0005743];
mitochondrion [GO:0005739];
myelin sheath [GO:0043209];
nucleoplasm [GO:0005654];
nucleus [GO:0005634];
plasma membrane [GO:0005886]
Protein-protein interaction111264
Phylogenetic treeP35232
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD31.934250725367151.09534954439994e-081.2807686837235e-07
AZA vs. DISU-0.2744813527926910.2785537593335230.848856084722281
AZA vs. IL70.5106507095489740.008106225189444590.284151470419764
AZA vs. SAHA-0.2399644492037160.3260215336445120.697501701161584
DISU vs. CD3-2.220519601304114.42663405930688e-097.54831242194478e-08
DISU vs. IL70.7756971145195240.002205742667076290.0453636708133358
DISU vs. SAHA0.03616566313017410.9012744262321590.976188803154228
DMSO vs. AZA-0.02199090719720830.8958478909269671
DMSO vs. CD3-1.967711746238562.73063771594195e-093.26225671615111e-08
DMSO vs. DISU0.2505160758996040.3051418390433780.811498856723186
DMSO vs. IL70.5399856942882180.002767444541732390.101754210894185
DMSO vs. SAHA-0.224221459319060.3422360139543910.694498201293955
HIV vs. Mock in Activation0.04483807953168470.9425974280745560.999983755607037
HIV vs. Mock in Latency-0.08846174275829860.5949325208969230.999834320637052
IL7 vs. CD3-1.41663044963541.46727632411858e-050.000108200861220349
SAHA vs. CD3-2.198160800245752.44303066665452e-093.74913158314497e-08
SAHA vs. IL7-0.7532792722936690.002097785325416710.020358334158571
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) FALSE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.338217 0.0108507
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
1.005 0.964 1.021 0.989 0.877
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
1LU7 Model - A=1-272.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Envelope surface glycoprotein gp160; precursor binds 19906925
Envelope surface glycoprotein gp120 complexes with 23125841
Gag-Pol complexes with 23125841
Envelope surface glycoprotein gp160; precursor interacts with 22190034
Vpr downregulates 23874603
Envelope transmembrane glycoprotein gp41 interacts with 22190034
Pr55(Gag) complexes with 23125841
Tat upregulates 23166591
Vpr modulates 19655254
Envelope surface glycoprotein gp120 upregulates 17676665
Nef complexes with 23125841

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
not found