Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0002133
UniProt IDQ15121
Primary gene name(s)PEA15
Synonym gene name(s)unknown
Protein nameAstrocytic phosphoprotein PEA-15
Protein functionBlocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm, By similarity. Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface. {ECO:0000250, ECO:0000269|PubMed:10442631, ECO:0000269|PubMed:9670003}.
Subcellular locationCytoplasm. Note=Associated with microtubules.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q15121
Gene Ontology
(Biological Process)
Complete annatation
activation of MAPK activity [GO:0000187];
apoptotic process [GO:0006915];
carbohydrate transport [GO:0008643];
DNA damage checkpoint [GO:0000077];
MAPK cascade [GO:0000165];
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042];
negative regulation of glucose import [GO:0046325];
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902043];
response to morphine [GO:0043278];
transport [GO:0006810]
Gene Ontology
(Molecular Function)
Complete annatation
Gene Ontology
(Cellular Component)
Complete annatation
cytosol [GO:0005829];
microtubule associated complex [GO:0005875]
Protein-protein interaction114230
Phylogenetic treeQ15121
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD30.9472157386218360.004383523591844910.013008164515906
AZA vs. DISU0.2861458022410470.2595173458948750.839581352451412
AZA vs. IL7-0.08724229917199950.6520111981528250.999311006273513
AZA vs. SAHA0.1017849079556690.6777011277117860.906126201803039
DISU vs. CD3-0.673739891503070.06792464218949310.137999289613484
DISU vs. IL7-0.3823015027081380.1321801049268060.475450985867718
DISU vs. SAHA-0.1836434100591820.5312097646543040.842279049248293
DMSO vs. AZA-0.03132659714813090.8776256645663151
DMSO vs. CD3-0.9951043042497470.002135718140143790.00659315446337423
DMSO vs. DISU-0.3211007277468150.1904088259046360.706763794675583
DMSO vs. IL7-0.04779033193394310.791508152499270.957493337259042
DMSO vs. SAHA0.1271978821545190.5905188786016160.860094088595918
HIV vs. Mock in Activation-0.1549709200260280.8031783745704480.999983755607037
HIV vs. Mock in Latency-0.3757209888451260.1767425937913390.999834320637052
IL7 vs. CD3-1.026017737705210.0016037679778510.00636649848041826
SAHA vs. CD3-0.871570325241770.01442968251851270.0349381933730699
SAHA vs. IL70.1850628365902140.4483632841237510.687061923846846
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock 0.773 8.53E-11 1.41E-08
Infected vs. Bystander 0.903 3.59E-12 6.41E-10
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) TRUE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.458352 0.000305467
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
0.934 1.027 1.214 1.565 1.199
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
4IZ5 X-ray 3.1Å E/F/G/H=1-130.
4IZA X-ray 1.9Å B=1-96.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
not found