Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0002123
UniProt IDP11177
Primary gene name(s)PDHB
Synonym gene name(s)PHE1B
Protein namePyruvate dehydrogenase E1 component subunit beta, mitochondrial
Protein functionThe pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2, and thereby links the glycolytic pathway to the tricarboxylic cycle. {ECO:0000269|PubMed:17474719, ECO:0000269|PubMed:19081061}.
Subcellular locationMitochondrion matrix.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P11177
Gene Ontology
(Biological Process)
Complete annatation
acetyl-CoA biosynthetic process from pyruvate [GO:0006086];
glucose metabolic process [GO:0006006];
glyoxylate metabolic process [GO:0046487];
mitochondrial acetyl-CoA biosynthetic process from pyruvate [GO:0061732];
pyruvate metabolic process [GO:0006090];
regulation of acetyl-CoA biosynthetic process from pyruvate [GO:0010510];
tricarboxylic acid cycle [GO:0006099]
Gene Ontology
(Molecular Function)
Complete annatation
pyruvate dehydrogenase, acetyl-transferring activity [GO:0004739];
pyruvate dehydrogenase activity [GO:0004738]
Gene Ontology
(Cellular Component)
Complete annatation
extracellular exosome [GO:0070062];
mitochondrial matrix [GO:0005759];
mitochondrion [GO:0005739];
nucleoplasm [GO:0005654];
nucleus [GO:0005634];
pyruvate dehydrogenase complex [GO:0045254]
Protein-protein interaction111188
Phylogenetic treeP11177
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD30.3363967474639540.3093080841604530.428364554301787
AZA vs. DISU-0.02359654961195110.925753686136710.995042856396371
AZA vs. IL70.05883311881562630.7601867314349420.999311006273513
AZA vs. SAHA-0.9113897091102230.0002479653348943510.00756645639311225
DISU vs. CD3-0.3727939889838880.3107214446570410.442894450544006
DISU vs. IL70.07314058900579350.7720009008942690.946588786123503
DISU vs. SAHA-0.8862779916449770.002923843305618230.0444779456385558
DMSO vs. AZA-0.04235223039760440.801137524617761
DMSO vs. CD3-0.3902254141387280.2268252632706310.330348278342233
DMSO vs. DISU-0.02053907836229660.932996523065940.991136162597188
DMSO vs. IL70.1082951832477620.5480589886150660.897425363918391
DMSO vs. SAHA-0.8752553508494290.0002651606759103140.00704803623746798
HIV vs. Mock in Activation0.02093199503788660.9731664985301070.999983755607037
HIV vs. Mock in Latency0.03343701109088450.8400447664570110.999834320637052
IL7 vs. CD3-0.2701796487874910.4031591389463150.540401752008697
SAHA vs. CD3-1.272010306567690.0003915040606503610.00158143737369424
SAHA vs. IL7-0.9731811981023828.47699789533474e-050.00171289901171952
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) FALSE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.30311 0.022374
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
1.044 0.947 1.035 1.039 0.865
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
211023_at 1.42 Yes upregulated in CD4+ cells
211023_at 1.54 Yes upregulated in CD8+ cells

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

Drugbank ID Drug Name Drug Status Pharmacological Action Drug Action
DB00119 Pyruvic acid approved, nutraceutical unknown unknown
DB00157 NADH nutraceutical unknown unknown

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
1NI4 X-ray 1.9Å B/D=31-359.
2OZL X-ray 1.9Å B/D=32-359.
3EXE X-ray 1.9Å B/D/F/H=31-359.
3EXF X-ray 3.0Å B/D/F/H=31-359.
3EXG X-ray 3.0Å 2/4/6/B/D/F/H/J/L/N/P/R/T/V/X/Z=31-359.
3EXH X-ray 2.4Å B/D/F/H=31-359.
3EXI X-ray 2.2Å B=31-359.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Envelope surface glycoprotein gp120 complexes with 23125841
Gag-Pol complexes with 23125841
Pr55(Gag) complexes with 23125841
Nef complexes with 23125841

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa00010 Glycolysis / Gluconeogenesis - Homo sapiens (human)
hsa00020 Citrate cycle (TCA cycle) - Homo sapiens (human)
hsa00620 Pyruvate metabolism - Homo sapiens (human)
hsa01100 Metabolic pathways - Homo sapiens (human)
hsa01200 Carbon metabolism - Homo sapiens (human)
hsa04066 HIF-1 signaling pathway - Homo sapiens (human)
hsa04922 Glucagon signaling pathway - Homo sapiens (human)
hsa05230 Central carbon metabolism in cancer - Homo sapiens (human)