Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0002120
UniProt IDP18545
Primary gene name(s)PDE6G
Synonym gene name(s)PDEG
Protein nameRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
Protein functionParticipates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.
Subcellular locationunknown
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P18545
Gene Ontology
(Biological Process)
Complete annatation
activation of MAPK activity [GO:0000187];
positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742];
positive regulation of G-protein coupled receptor protein signaling pathway [GO:0045745];
regulation of rhodopsin mediated signaling pathway [GO:0022400];
rhodopsin mediated signaling pathway [GO:0016056];
visual perception [GO:0007601];
Wnt signaling pathway, calcium modulating pathway [GO:0007223]
Gene Ontology
(Molecular Function)
Complete annatation
3',5'-cyclic-GMP phosphodiesterase activity [GO:0047555];
cGMP binding [GO:0030553];
enzyme inhibitor activity [GO:0004857]
Gene Ontology
(Cellular Component)
Complete annatation
photoreceptor disc membrane [GO:0097381];
plasma membrane [GO:0005886]
Protein-protein interaction111174
Phylogenetic treeP18545
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-2.533334968463540.0002150561966013380.000944707138638672
AZA vs. DISU-0.8065670987250130.00286310321982430.138548566832274
AZA vs. IL7-0.2944882306477390.2073320152134590.971990860091009
AZA vs. SAHA-2.210387242438034.86576657965365e-075.23904038726423e-05
DISU vs. CD31.713963628343060.01160598493049580.0328049159651779
DISU vs. IL70.5012193476541460.06359293595393330.333332235572164
DISU vs. SAHA-1.399722517781620.001400345775543930.0260574807219597
DMSO vs. AZA-0.01202436780410.9489689202933151
DMSO vs. CD32.504400100648570.0001727607652265430.000729848830100355
DMSO vs. DISU0.791194108618450.002418913562722950.104437980025437
DMSO vs. IL7-0.2738592206891630.1718487127391080.68264430801014
DMSO vs. SAHA-2.199694999444041.11145513792543e-071.31077478473787e-05
HIV vs. Mock in Activation-0.1346674922379970.9224399310113980.999983755607037
HIV vs. Mock in Latency-0.06685857496387060.7749272411821330.999834320637052
IL7 vs. CD32.246529102960610.0008904805954224050.00384040458220369
SAHA vs. CD30.2981849105681850.685014206804350.767806924250023
SAHA vs. IL7-1.918853534702411.67340848613584e-050.000463703063390902
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) TRUE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.198195 0.272354
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

Drugbank ID Drug Name Drug Status Pharmacological Action Drug Action
DB00203 Sildenafil approved, investigational unknown inhibitor
DB00862 Vardenafil approved unknown allosteric modulator
DB07954 3-isobutyl-1-methyl-7H-xanthine experimental unknown unknown

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
3JWR X-ray 2.9Å C/D=70-87.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa00230 Purine metabolism - Homo sapiens (human)
hsa04744 Phototransduction - Homo sapiens (human)