Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0002118
UniProt IDQ01064
Primary gene name(s)PDE1B
Synonym gene name(s)PDE1B1, PDES1B
Protein nameCalcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
Protein functionCyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a preference for cGMP as a substrate. {ECO:0000269|PubMed:15260978}.
Subcellular locationCytoplasm.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q01064
Gene Ontology
(Biological Process)
Complete annatation
apoptotic process [GO:0006915];
cAMP catabolic process [GO:0006198];
cellular response to granulocyte macrophage colony-stimulating factor stimulus [GO:0097011];
cellular response to macrophage colony-stimulating factor stimulus [GO:0036006];
cGMP catabolic process [GO:0046069];
locomotory behavior [GO:0007626];
monocyte differentiation [GO:0030224];
regulation of dopamine metabolic process [GO:0042053];
regulation of neurotransmitter levels [GO:0001505];
response to amphetamine [GO:0001975];
serotonin metabolic process [GO:0042428];
signal transduction [GO:0007165];
visual learning [GO:0008542]
Gene Ontology
(Molecular Function)
Complete annatation
3',5'-cyclic-AMP phosphodiesterase activity [GO:0004115];
3',5'-cyclic-GMP phosphodiesterase activity [GO:0047555];
calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity [GO:0048101];
calmodulin-dependent cyclic-nucleotide phosphodiesterase activity [GO:0004117];
metal ion binding [GO:0046872]
Gene Ontology
(Cellular Component)
Complete annatation
cytosol [GO:0005829];
neuronal cell body [GO:0043025]
Protein-protein interaction111179
Phylogenetic treeQ01064
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
      unknown
Brass et al., Science, 2008
      unknown
Smith et al., J. Immunol, 2010
      unknown
Interferon-stimulated
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model


DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD31.845939736633091.15498607122788e-071.09690926689015e-06
AZA vs. DISU1.551591378230225.35520545703605e-050.0104836840336833
AZA vs. IL70.04589744258481050.8304334368440630.999311006273513
AZA vs. SAHA0.5959330938144090.02249222862528320.166444700195149
DISU vs. CD3-0.3124839565944980.4298577056805350.561567634726756
DISU vs. IL7-1.513868757643492.92330933379104e-050.00204971573055348
DISU vs. SAHA-0.9495131601793890.01029287063377860.105383052528313
DMSO vs. AZA0.2727677536476730.154777732660321
DMSO vs. CD3-1.585725591125682.08713915439418e-061.39807698359041e-05
DMSO vs. DISU-1.278082535334680.0002375294717144040.0261282418885844
DMSO vs. IL7-0.2203842875380360.2682692692348680.767539423873874
DMSO vs. SAHA0.3184486340236070.2004367729577370.539087794598268
HIV vs. Mock in Activation0.0664308100366720.9154335172102220.999983755607037
HIV vs. Mock in Latency0.08917710768974460.6238315407837050.999834320637052
IL7 vs. CD3-1.797473084819671.13726460027053e-071.36469439446135e-06
SAHA vs. CD3-1.272804900876820.0004613586359372150.00182724694969089
SAHA vs. IL70.5502870347448280.03302153646317520.139170425684927
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) TRUE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.85371 0.000305467
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
1.064 1.046 1.286 1.258 1.088
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

Drugbank ID Drug Name Drug Status Pharmacological Action Drug Action
DB04530 S,S-(2-Hydroxyethyl)Thiocysteine experimental unknown unknown
DB01023 Felodipine approved, investigational unknown inhibitor
DB00622 Nicardipine approved unknown inhibitor
DB01244 Bepridil approved, withdrawn unknown inhibitor
DB00201 Caffeine approved unknown inhibitor, competitive

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
1LXR Model - A=158-461.
1TAZ X-ray 1.7Å A=146-506.
4NPV X-ray 2.4Å A=142-507.
4NPW X-ray 1.9Å A=142-507.
5B25 X-ray 1.9Å A/B/C/D=146-506.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Tat activates 11156964

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa00230 Purine metabolism - Homo sapiens (human)
hsa04020 Calcium signaling pathway - Homo sapiens (human)
hsa04740 Olfactory transduction - Homo sapiens (human)
hsa04742 Taste transduction - Homo sapiens (human)
hsa04924 Renin secretion - Homo sapiens (human)
hsa05032 Morphine addiction - Homo sapiens (human)
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