Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0002071
UniProt IDQ93086
Primary gene name(s)P2RX5
Synonym gene name(s)P2X5
Protein nameP2X purinoceptor 5
Protein functionReceptor for ATP that acts as a ligand-gated ion channel.
Subcellular locationMembrane;
Multi-pass membrane protein.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q93086
Gene Ontology
(Biological Process)
Complete annatation
blood coagulation [GO:0007596];
nervous system development [GO:0007399];
positive regulation of calcium ion transport into cytosol [GO:0010524];
positive regulation of calcium-mediated signaling [GO:0050850];
response to ATP [GO:0033198];
signal transduction [GO:0007165];
transport [GO:0006810]
Gene Ontology
(Molecular Function)
Complete annatation
ATP binding [GO:0005524];
extracellular ATP-gated cation channel activity [GO:0004931];
ion channel activity [GO:0005216];
purinergic nucleotide receptor activity [GO:0001614];
transmembrane signaling receptor activity [GO:0004888]
Gene Ontology
(Cellular Component)
Complete annatation
cytoplasm [GO:0005737];
integral component of nuclear inner membrane [GO:0005639];
integral component of plasma membrane [GO:0005887];
plasma membrane [GO:0005886]
Protein-protein interaction111065
Phylogenetic treeQ93086
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
      Yes - Two siRNA pools inhibit HIV replication and inhibition of Tat-mediated transactivation of the HIV LTR is not observed
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD31.412871859066720.0004501178099864940.00181395070377445
AZA vs. DISU-0.3032298930727390.451645501283750.920247052782372
AZA vs. IL70.3349098187288530.09263585310027330.819906173681985
AZA vs. SAHA-1.087319359112390.00168087970491970.0295934710111756
DISU vs. CD3-1.728678598911290.001025746225357340.00424549659556192
DISU vs. IL70.6285901450008590.1055724313358580.427199793530442
DISU vs. SAHA-0.783509606976230.1207187284524370.445919597183008
DMSO vs. AZA0.1034786217169690.576506008735241
DMSO vs. CD3-1.321531031417030.0005727991316261120.00210417432771211
DMSO vs. DISU0.4046296442805060.2935700947782220.806581828315005
DMSO vs. IL70.2389557672834810.1988812874403470.709449930942552
DMSO vs. SAHA-1.196736813765850.0002022967762902450.00586351082920423
HIV vs. Mock in Activation0.1345605231495630.8701219924232770.999983755607037
HIV vs. Mock in Latency-0.1480509298721180.386734191983910.999834320637052
IL7 vs. CD3-1.071303692805120.00464764350990010.0157601643700167
SAHA vs. CD3-2.52479796597025.93811376736753e-075.11356425567021e-06
SAHA vs. IL7-1.426360018944167.15556353947377e-060.000233639745296864
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
0.3499 0.03119

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) FALSE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.452755 0.0175948
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
HIV-1 virus replication regulated by expression of human gene 18976975

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04020 Calcium signaling pathway - Homo sapiens (human)
hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human)