Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0002069
UniProt IDP51575
Primary gene name(s)P2RX1
Synonym gene name(s)P2X1
Protein nameP2X purinoceptor 1
Protein functionLigand-gated ion channel with relatively high calcium permeability. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Seems to be linked to apoptosis, by increasing the intracellular concentration of calcium in the presence of ATP, leading to programmed cell death, By similarity. {ECO:0000250}.
Subcellular locationMembrane;
Multi-pass membrane protein.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P51575
Gene Ontology
(Biological Process)
Complete annatation
activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919];
apoptotic process [GO:0006915];
blood coagulation [GO:0007596];
ceramide biosynthetic process [GO:0046513];
insemination [GO:0007320];
ion transport [GO:0006811];
neuronal action potential [GO:0019228];
platelet activation [GO:0030168];
positive regulation of ion transport [GO:0043270];
protein heterooligomerization [GO:0051291];
protein homooligomerization [GO:0051260];
regulation of blood pressure [GO:0008217];
regulation of calcium ion transport [GO:0051924];
regulation of vascular smooth muscle contraction [GO:0003056];
response to ATP [GO:0033198];
serotonin secretion by platelet [GO:0002554];
signal transduction [GO:0007165];
synaptic transmission, glutamatergic [GO:0035249];
transport [GO:0006810];
vasoconstriction [GO:0042310]
Gene Ontology
(Molecular Function)
Complete annatation
ATP binding [GO:0005524];
cation channel activity [GO:0005261];
drug binding [GO:0008144];
extracellular ATP-gated cation channel activity [GO:0004931];
purinergic nucleotide receptor activity [GO:0001614];
zinc ion binding [GO:0008270]
Gene Ontology
(Cellular Component)
Complete annatation
external side of cell outer membrane [GO:0031240];
integral component of nuclear inner membrane [GO:0005639];
integral component of plasma membrane [GO:0005887];
membrane raft [GO:0045121];
neuron projection [GO:0043005];
plasma membrane [GO:0005886];
postsynaptic membrane [GO:0045211];
protein complex [GO:0043234]
Protein-protein interaction111062
Phylogenetic treeP51575
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-3.467907444064874.5273150374614e-050.000239507519286129
AZA vs. DISU-0.212390273165830.6347960387406760.960057478314726
AZA vs. IL7-0.1179659975512070.7161139342649730.999311006273513
AZA vs. SAHA-1.079619851508390.01121490680458310.105067436402913
DISU vs. CD33.240777620438880.0006405369419368870.00281254117761626
DISU vs. IL70.08100412151755860.851993220899840.970365378389648
DISU vs. SAHA-0.86683700472270.1044838128307270.414824958685956
DMSO vs. AZA0.06134888542759330.8368184062689061
DMSO vs. CD33.5089302998992.30470114815917e-050.00012156975769264
DMSO vs. DISU0.2700364471381510.5132382543376940.912102132233928
DMSO vs. IL7-0.1701502308566830.5382225591144990.896696737481162
DMSO vs. SAHA-1.141455032927110.003043831092488620.0391045973295365
HIV vs. Mock in Activationunknownunknownunknown
HIV vs. Mock in Latency0.1900008823729940.3046089835334280.999834320637052
IL7 vs. CD33.352538478843955.16958030731818e-050.000327399512488264
SAHA vs. CD3unknownunknownunknown
SAHA vs. IL7-0.963686321436930.01617279167008050.0875677663918077
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) FALSE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 1.18425 0.00261319
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Envelope surface glycoprotein gp120 stimulates 22450808
Envelope surface glycoprotein gp120 interacts with 25031337
Envelope transmembrane glycoprotein gp41 interacts with 25031337

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04020 Calcium signaling pathway - Homo sapiens (human)
hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human)
hsa04611 Platelet activation - Homo sapiens (human)