Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0002047
UniProt IDO75665
Primary gene name(s)OFD1
Synonym gene name(s)CXorf5
Protein nameOral-facial-digital syndrome 1 protein
Protein functionComponent of the centrioles controlling mother and daughter centrioles length. Recruits to the centriole IFT88 and centriole distal appendage-specific proteins including CEP164. Involved in the biogenesis of the cilium, a centriole-associated function. The cilium is a cell surface projection found in many vertebrate cells required to transduce signals important for development and tissue homeostasis. Plays an important role in development by regulating Wnt signaling and the specification of the left-right axis. Only OFD1 localized at the centriolar satellites is removed by autophagy, which is an important step in the ciliogenesis regulation, By similarity. {ECO:0000250}.
Subcellular locationCytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:12595504, ECO:0000269|PubMed:14654843, ECO:0000269|PubMed:20230748, ECO:0000269|PubMed:26643951}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:17761535}. Nucleus {ECO:0000269|PubMed:17761535}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000269|PubMed:24121310, ECO:0000269|PubMed:26643951}. Note=Localizes to centriole distal ends and to centriolar satellites, PubMed:20230748, PubMed:24121310. Localization to centrioles and pericentriolar satellites may be mediated by KIAA0753/OFIP, PubMed:26643951. {ECO:0000269|PubMed:26643951}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: O75665
Gene Ontology
(Biological Process)
Complete annatation
cilium assembly [GO:0060271];
epithelial cilium movement involved in determination of left/right asymmetry [GO:0060287];
G2/M transition of mitotic cell cycle [GO:0000086]
Gene Ontology
(Molecular Function)
Complete annatation
alpha-tubulin binding [GO:0043014];
gamma-tubulin binding [GO:0043015];
identical protein binding [GO:0042802]
Gene Ontology
(Cellular Component)
Complete annatation
centriolar satellite [GO:0034451];
centriole [GO:0005814];
centrosome [GO:0005813];
ciliary basal body [GO:0036064];
cilium [GO:0005929];
cytosol [GO:0005829];
membrane [GO:0016020];
microtubule cytoskeleton [GO:0015630];
nucleus [GO:0005634]
Protein-protein interaction114055
Phylogenetic treeO75665
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-0.7573396059019630.02202561716560890.0503595421602029
AZA vs. DISU-0.1016450079663110.6888713087996440.968313969505284
AZA vs. IL7-0.2823846407023780.1429668468584260.907864810288571
AZA vs. SAHA-0.2000420217325930.4128949464554370.767967971911865
DISU vs. CD30.6421599132523340.07750609957739710.152556512082708
DISU vs. IL7-0.1897960198275360.4525708509922750.797170491837635
DISU vs. SAHA-0.09704471542514010.740757732739310.92537457843182
DMSO vs. AZA-0.08909019401434640.5957418385923331
DMSO vs. CD30.6576834389646040.04130035292001710.0818347779481859
DMSO vs. DISU0.01109673462407510.963828489874190.994294013509907
DMSO vs. IL7-0.1863334924038570.301275403330230.786292021121545
DMSO vs. SAHA-0.1181706838073030.6167323671159990.873815314920111
HIV vs. Mock in Activation0.1326913682902840.8311893283553750.999983755607037
HIV vs. Mock in Latency0.111398369077520.4997723215701560.999834320637052
IL7 vs. CD30.4825209752529530.1354817223326660.23948821399323
SAHA vs. CD30.5323121023399290.1359758748986720.222601786283297
SAHA vs. IL70.0783191458640790.748166673684550.886136908864689
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) TRUE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.139459 0.481594
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
not found