Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0002046
UniProt IDP11926
Primary gene name(s)ODC1
Synonym gene name(s)unknown
Protein nameOrnithine decarboxylase
Protein functionKey enzyme of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. {ECO:0000269|PubMed:17900240}.
Subcellular locationunknown
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P11926
Gene Ontology
(Biological Process)
Complete annatation
kidney development [GO:0001822];
polyamine metabolic process [GO:0006595];
positive regulation of cell proliferation [GO:0008284];
putrescine biosynthetic process from ornithine [GO:0033387];
regulation of cellular amino acid metabolic process [GO:0006521];
regulation of protein catabolic process [GO:0042176];
response to virus [GO:0009615]
Gene Ontology
(Molecular Function)
Complete annatation
ornithine decarboxylase activity [GO:0004586];
protein homodimerization activity [GO:0042803]
Gene Ontology
(Cellular Component)
Complete annatation
cytoplasm [GO:0005737];
cytosol [GO:0005829];
perinuclear region of cytoplasm [GO:0048471]
Protein-protein interaction111007
Phylogenetic treeP11926
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD32.903908028890145.55111512312578e-162.15635069937505e-14
AZA vs. DISU-0.4596379255139030.07199249578642210.582196824830755
AZA vs. IL70.5976704237660690.01809119132389360.436597117879048
AZA vs. SAHA-0.7551264514511930.0199455016609880.153846888789199
DISU vs. CD3-3.3771708526011500
DISU vs. IL71.048735939960043.82183826334037e-050.00249412172380329
DISU vs. SAHA-0.294414903183180.3178619172319240.70026267425849
DMSO vs. AZA-0.03323713708842370.9046715802545621
DMSO vs. CD3-2.9516994816402100
DMSO vs. DISU0.4234266609019530.08495085693365190.539021240397609
DMSO vs. IL70.6388693168263510.004512007007468120.13528560326202
DMSO vs. SAHA-0.7283961373961250.01595796592738390.12202055022405
HIV vs. Mock in Activation-0.2556255387952340.6808484748236140.999983755607037
HIV vs. Mock in Latency-0.2649186347765340.1102718979043820.999834320637052
IL7 vs. CD3-2.29755017396861.43391964968487e-113.48180272573536e-10
SAHA vs. CD3-3.6853403516905100
SAHA vs. IL7-1.356969876997721.67072042533967e-067.04751134343277e-05
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change -2.058381858
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) FALSE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.481546 0.0212732
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

Drugbank ID Drug Name Drug Status Pharmacological Action Drug Action
DB00114 Pyridoxal Phosphate nutraceutical unknown cofactor
DB01917 Putrescine experimental unknown unknown
DB02209 Pyridoxine-5&,39;-Phosphate experimental unknown unknown
DB02824 N-Pyridoxyl-Glycine-5-Monophosphate experimental unknown unknown
DB03856 Alpha-Difluoromethylornithine experimental unknown unknown
DB04083 N&,39;-Pyridoxyl-Lysine-5&,39;-Monophosphate experimental unknown unknown
DB04263 Geneticin experimental unknown unknown
DB00127 Spermine approved, nutraceutical unknown product of
DB06243 Eflornithine approved, withdrawn yes antagonist

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
1D7K X-ray 2.1Å A/B=7-427.
2ON3 X-ray 3.0Å A/B=1-461.
2OO0 X-ray 1.9Å A/B=1-461.
4ZGY X-ray 2.6Å A=2-421.
5BWA X-ray 3.2Å A=1-461.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa00330 Arginine and proline metabolism - Homo sapiens (human)
hsa00480 Glutathione metabolism - Homo sapiens (human)
hsa01100 Metabolic pathways - Homo sapiens (human)