Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0002042
UniProt IDP04181
Primary gene name(s)OAT
Synonym gene name(s)unknown
Protein nameOrnithine aminotransferase, mitochondrial
Protein functionunknown
Subcellular locationMitochondrion matrix {ECO:0000269|PubMed:23076989}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P04181
Gene Ontology
(Biological Process)
Complete annatation
arginine catabolic process to glutamate [GO:0019544];
arginine catabolic process to proline via ornithine [GO:0010121];
cellular amino acid biosynthetic process [GO:0008652];
L-proline biosynthetic process [GO:0055129];
protein hexamerization [GO:0034214];
visual perception [GO:0007601]
Gene Ontology
(Molecular Function)
Complete annatation
identical protein binding [GO:0042802];
ornithine-oxo-acid transaminase activity [GO:0004587];
pyridoxal phosphate binding [GO:0030170]
Gene Ontology
(Cellular Component)
Complete annatation
mitochondrial matrix [GO:0005759];
mitochondrion [GO:0005739]
Protein-protein interaction110996
Phylogenetic treeP04181
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
      unknown
Brass et al., Science, 2008
      unknown
Smith et al., J. Immunol, 2010
      unknown
Interferon-stimulated
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model


DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD30.9208237307227760.00531328069330150.0152536698303696
AZA vs. DISU0.0461046735411550.8559910390057380.989951370113767
AZA vs. IL70.234238356145170.225457568724470.989265982093417
AZA vs. SAHA0.1540803720835540.5288564332043670.837237848469596
DISU vs. CD3-0.8870336351298770.01510704408266580.0408841071640172
DISU vs. IL70.1792571062417610.4786373832038470.81294126650647
DISU vs. SAHA0.1091047755405270.7093002764119280.914054251030711
DMSO vs. AZA-0.03563256630667280.8328478176986751
DMSO vs. CD3-0.9693634538122310.00268713800873510.00807374034734629
DMSO vs. DISU-0.08390460552916470.7322078849188450.966567788429311
DMSO vs. IL70.2772429063047350.1252152280231920.620616381394679
DMSO vs. SAHA0.1835523679829220.437515234734580.771178501939832
HIV vs. Mock in Activation-0.2370367416393170.7032558234007470.999983755607037
HIV vs. Mock in Latency-0.07223442155939460.6647272902527590.999834320637052
IL7 vs. CD3-0.6784457078617850.0355848480865690.0834829459086822
SAHA vs. CD3-0.7915854157526610.02611937897054380.0576428827266097
SAHA vs. IL7-0.0833966149801360.7325220273122280.878094396795588
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) FALSE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.505437 0.00420274
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
201599_at 1.36 No downregulated in CD8+ cells

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

Drugbank ID Drug Name Drug Status Pharmacological Action Drug Action
DB00129 L-Ornithine approved, nutraceutical unknown unknown
DB00114 Pyridoxal Phosphate nutraceutical unknown cofactor
DB02054 Gabaculine experimental unknown unknown
DB02821 Canaline experimental unknown inhibitor

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
1GBN X-ray 2.3Å A/B/C=38-439.
1OAT X-ray 2.5Å A/B/C=1-439.
2BYJ X-ray 3.0Å A/B/C=1-439.
2BYL X-ray 2.1Å A/B/C=1-439.
2CAN X-ray 2.3Å A/B/C=38-439.
2OAT X-ray 1.9Å A/B/C=1-439.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Envelope surface glycoprotein gp120 complexes with 23125841
Gag-Pol complexes with 23125841
Pr55(Gag) complexes with 23125841
Envelope surface glycoprotein gp120 upregulates 17676665
Nef complexes with 23125841

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa00330 Arginine and proline metabolism - Homo sapiens (human)
hsa01100 Metabolic pathways - Homo sapiens (human)
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