Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0002035
UniProt IDQ8N1F7
Primary gene name(s)NUP93
Synonym gene name(s)KIAA0095
Protein nameNuclear pore complex protein Nup93
Protein functionPlays a role in the nuclear pore complex, NPC assembly and/or maintenance. May anchor nucleoporins, but not NUP153 and TPR, to the NPC. During renal development, regulates podocyte migration and proliferation through SMAD4 signaling, PubMed:26878725. {ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:15703211, ECO:0000269|PubMed:26878725}.
Subcellular locationNucleus membrane {ECO:0000250|UniProtKB:Q66HC5};
Peripheral membrane protein {ECO:0000250|UniProtKB:Q66HC5}. Nucleus, nuclear pore complex {ECO:0000269|PubMed:12802065, ECO:0000269|PubMed:15229283}. Nucleus envelope {ECO:0000269|PubMed:26878725}. Note=Localizes at the nuclear basket and at or near the nuclear entry to the gated channel of the pore.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q8N1F7
Gene Ontology
(Biological Process)
Complete annatation
gene silencing by RNA [GO:0031047];
glomerular visceral epithelial cell development [GO:0072015];
glomerular visceral epithelial cell migration [GO:0090521];
intracellular transport of virus [GO:0075733];
mitotic nuclear envelope disassembly [GO:0007077];
mRNA export from nucleus [GO:0006406];
negative regulation of hydrogen peroxide-induced cell death [GO:1903206];
nuclear envelope organization [GO:0006998];
nuclear pore complex assembly [GO:0051292];
poly(A+ mRNA export from nucleus [GO:0016973];
positive regulation of SMAD protein import into nucleus [GO:0060391];
protein import into nucleus [GO:0006606];
protein sumoylation [GO:0016925];
regulation of cellular response to heat [GO:1900034];
regulation of glucose transport [GO:0010827];
renal system development [GO:0072001];
SMAD protein signal transduction [GO:0060395];
tRNA export from nucleus [GO:0006409];
viral process [GO:0016032];
viral transcription [GO:0019083]
Gene Ontology
(Molecular Function)
Complete annatation
structural constituent of nuclear pore [GO:0017056]
Gene Ontology
(Cellular Component)
Complete annatation
membrane [GO:0016020];
nuclear envelope [GO:0005635];
nuclear membrane [GO:0031965];
nuclear periphery [GO:0034399];
nuclear pore [GO:0005643]
Protein-protein interaction115041
Phylogenetic treeQ8N1F7
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD31.527824470133654.99592941616278e-063.30692350287244e-05
AZA vs. DISU-0.1205662392655830.6351461279821360.960057478314726
AZA vs. IL70.307041143923970.1128792045579240.863301241827967
AZA vs. SAHA0.03955948584893780.871754064039530.97087704184203
DISU vs. CD3-1.660631862297497.93616228866867e-066.07565821936981e-05
DISU vs. IL70.4186810766207770.09812883116760010.414599812178131
DISU vs. SAHA0.1614368876356510.5805359726576420.865147684815138
DMSO vs. AZA0.07023649369664170.6782331773725911
DMSO vs. CD3-1.47016874896186.59258152302389e-063.95528636576483e-05
DMSO vs. DISU0.1887452077532080.4410145746399640.884783740848831
DMSO vs. IL70.2442501266265810.177339326411210.688068700883369
DMSO vs. SAHA-0.03707445494051750.8755178412337790.969166253985955
HIV vs. Mock in Activation0.06171728423493380.9209231528079250.999983755607037
HIV vs. Mock in Latency-0.1589135276478240.3416985149617250.999834320637052
IL7 vs. CD3-1.213275904883480.0001946153396621410.00104139862128662
SAHA vs. CD3-1.51350048042332.73274478180818e-050.000152753946075109
SAHA vs. IL7-0.2710472869240020.2675451619570850.514278981298279
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
-0.3295 0.03713

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) FALSE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.328097 0.0211328
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
1.007 0.974 0.928 0.906 0.913
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
5IJN EM 21.4Å C/I/O/U=1-819.
5IJO EM 21.4Å C/I/O/U=1-819.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Tat interacts with 19454010

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa03013 RNA transport - Homo sapiens (human)