Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0002026
UniProt IDQ12769
Primary gene name(s)NUP160
Synonym gene name(s)KIAA0197, NUP120
Protein nameNuclear pore complex protein Nup160
Protein functionInvolved in poly(A+ RNA transport. {ECO:0000269|PubMed:11684705}.
Subcellular locationNucleus, nuclear pore complex {ECO:0000269|PubMed:11564755, ECO:0000269|PubMed:11684705}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q12769
Gene Ontology
(Biological Process)
Complete annatation
gene silencing by RNA [GO:0031047];
intracellular transport of virus [GO:0075733];
mitotic nuclear envelope disassembly [GO:0007077];
mRNA export from nucleus [GO:0006406];
protein sumoylation [GO:0016925];
protein transport [GO:0015031];
regulation of cellular response to heat [GO:1900034];
regulation of glucose transport [GO:0010827];
sister chromatid cohesion [GO:0007062];
tRNA export from nucleus [GO:0006409];
viral process [GO:0016032];
viral transcription [GO:0019083]
Gene Ontology
(Molecular Function)
Complete annatation
nucleocytoplasmic transporter activity [GO:0005487]
Gene Ontology
(Cellular Component)
Complete annatation
cytosol [GO:0005829];
nuclear envelope [GO:0005635];
nuclear pore [GO:0005643];
nuclear pore outer ring [GO:0031080]
Protein-protein interaction116879
Phylogenetic treeQ12769
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD31.046635442258060.00161220383545380.00551000821042168
AZA vs. DISU0.2292443328575190.3660208337620550.896211275303082
AZA vs. IL70.2672858263268970.1649302834936560.931425241577222
AZA vs. SAHA-0.2848446417079250.2433571344638580.615059222972355
DISU vs. CD3-0.8300926310855490.02270943086843920.057167996144097
DISU vs. IL70.02919902087312220.9077037143742420.982189124739072
DISU vs. SAHA-0.512972996354660.0798762768056620.359200321199145
DMSO vs. AZA0.02619087786627050.8758554639632991
DMSO vs. CD3-1.032128407084790.001435752151002110.00468782101318743
DMSO vs. DISU-0.2049109299174050.4019663489134460.865499768270557
DMSO vs. IL70.2483880123022550.167507074173620.676241368052584
DMSO vs. SAHA-0.3178021047106190.1780828912110010.509782301781667
HIV vs. Mock in Activation0.09990672216287650.8726661181407780.999983755607037
HIV vs. Mock in Latency0.0008017270153814980.9961304272643830.999834320637052
IL7 vs. CD3-0.7714776098202440.01694519386148260.0460041259139279
SAHA vs. CD3-1.356581622660720.0001700597243509130.000765014939095002
SAHA vs. IL7-0.5558795346680.02295316871316490.109840020692777
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) FALSE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.306831 0.0688254
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
0.958 0.984 0.963 0.96 0.932
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
5A9Q EM 23.0Å 1/J/S/a=1-1436.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
HIV-1 virus replication enhanced by expression of human gene 18187620

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa03013 RNA transport - Homo sapiens (human)