Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0002025
UniProt IDO75694
Primary gene name(s)NUP155
Synonym gene name(s)KIAA0791
Protein nameNuclear pore complex protein Nup155
Protein functionEssential component of nuclear pore complex. Could be essessential for embryogenesis. Nucleoporins may be involved both in binding and translocating proteins during nucleocytoplasmic transport. {ECO:0000250|UniProtKB:Q99P88}.
Subcellular locationNucleus, nuclear pore complex {ECO:0000250|UniProtKB:P37199}. Nucleus membrane {ECO:0000250|UniProtKB:P37199};
Peripheral membrane protein {ECO:0000250|UniProtKB:P37199};
Cytoplasmic side {ECO:0000250|UniProtKB:P37199}. Nucleus membrane {ECO:0000250|UniProtKB:P37199};
Peripheral membrane protein {ECO:0000250|UniProtKB:P37199};
Nucleoplasmic side {ECO:0000250|UniProtKB:P37199}. Note=In mitosis, assumes a diffuse cytoplasmic distribution probably as a monomer, before reversing back into a punctate nuclear surface localization at the end of mitosis. {ECO:0000250|UniProtKB:P37199}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: O75694
Gene Ontology
(Biological Process)
Complete annatation
atrial cardiac muscle cell action potential [GO:0086014];
gene silencing by RNA [GO:0031047];
intracellular transport of virus [GO:0075733];
mitotic nuclear envelope disassembly [GO:0007077];
mRNA export from nucleus [GO:0006406];
nuclear envelope organization [GO:0006998];
protein import into nucleus [GO:0006606];
protein sumoylation [GO:0016925];
protein targeting to nuclear inner membrane [GO:0036228];
regulation of cellular response to heat [GO:1900034];
regulation of glucose transport [GO:0010827];
RNA export from nucleus [GO:0006405];
transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery [GO:0000972];
tRNA export from nucleus [GO:0006409];
viral process [GO:0016032];
viral transcription [GO:0019083]
Gene Ontology
(Molecular Function)
Complete annatation
structural constituent of nuclear pore [GO:0017056];
transporter activity [GO:0005215]
Gene Ontology
(Cellular Component)
Complete annatation
membrane [GO:0016020];
nuclear envelope [GO:0005635];
nuclear membrane [GO:0031965];
nuclear pore inner ring [GO:0044611]
Protein-protein interaction114990
Phylogenetic treeO75694
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD31.536682734545534.77365077533598e-063.17717919637193e-05
AZA vs. DISU-0.05972671492748520.8139079921646880.983626273983733
AZA vs. IL70.4017535102356590.0379820212349260.597602302791273
AZA vs. SAHA-0.004437997718349440.9855458679426490.997087719578447
DISU vs. CD3-1.6081730447721.58235933089834e-050.000111773592099164
DISU vs. IL70.4525578431337690.07367091048064790.360815131740015
DISU vs. SAHA0.05559243783330030.8489992726694220.960029114525874
DMSO vs. AZA-0.0812263729960280.6311894992304781
DMSO vs. CD3-1.628391498573017.49109716036145e-075.52390497899389e-06
DMSO vs. DISU-0.02310699918447160.9247858211383880.990161444018154
DMSO vs. IL70.4900169564378910.006887081421721010.173378076038115
DMSO vs. SAHA0.06899262252772090.770677225337460.934347716439616
HIV vs. Mock in Activation0.03881836241120070.9502692602872320.999983755607037
HIV vs. Mock in Latency-0.02584527346220390.876977168200440.999834320637052
IL7 vs. CD3-1.126139671396210.000541983228915410.0025090028284527
SAHA vs. CD3-1.566741044546551.63738579850303e-059.64636590439433e-05
SAHA vs. IL7-0.4102457779185580.09386301269837430.27714973970747
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) FALSE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.337769 0.0347711
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
0.977 0.955 0.904 0.886 0.913
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
5A9Q EM 23.0Å A/B=1-1391.
5IJN EM 21.4Å A/B/E/K/Q/W=1-1391.
5IJO EM 21.4Å A/B/E/K/Q/W=1-1391.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Envelope surface glycoprotein gp120 complexes with 23125841
Gag-Pol complexes with 23125841
Pr55(Gag) complexes with 23125841
HIV-1 virus replication enhanced by expression of human gene 18187620
Nef complexes with 23125841
capsid interacts with 20227665

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa03013 RNA transport - Homo sapiens (human)