Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0002022
UniProt IDP49757
Primary gene name(s)NUMB
Synonym gene name(s)unknown
Protein nameProtein numb homolog
Protein functionPlays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells, RGCs, by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone, SVZ neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage.
Subcellular locationMembrane;
Peripheral membrane protein.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P49757
Gene Ontology
(Biological Process)
Complete annatation
adherens junction organization [GO:0034332];
axonogenesis [GO:0007409];
lateral ventricle development [GO:0021670];
lung epithelial cell differentiation [GO:0060487];
negative regulation of Notch signaling pathway [GO:0045746];
negative regulation of protein localization to plasma membrane [GO:1903077];
neuroblast division in subventricular zone [GO:0021849];
positive regulation of cell migration [GO:0030335];
positive regulation of neurogenesis [GO:0050769];
positive regulation of polarized epithelial cell differentiation [GO:0030862]
Gene Ontology
(Molecular Function)
Complete annatation
Gene Ontology
(Cellular Component)
Complete annatation
apical part of cell [GO:0045177];
basolateral plasma membrane [GO:0016323];
clathrin-coated vesicle [GO:0030136];
early endosome [GO:0005769];
extrinsic component of plasma membrane [GO:0019897];
focal adhesion [GO:0005925];
nucleus [GO:0005634];
plasma membrane [GO:0005886]
Protein-protein interaction114202
Phylogenetic treeP49757
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD30.09112717104830570.7807596783847160.849646922210429
AZA vs. DISU0.007771790008083630.9755111227933190.997811953897277
AZA vs. IL7-0.07149175846602110.7109505836146110.999311006273513
AZA vs. SAHA0.1326940497468360.5871007924883240.863157841214181
DISU vs. CD3-0.09592374264842590.7912604909722770.856217528060801
DISU vs. IL7-0.0883865653868810.7259334139989560.930944114950367
DISU vs. SAHA0.1264584510050840.6646618426265230.89799360199232
DMSO vs. AZA-0.02642785919811410.875186871376571
DMSO vs. CD3-0.1291145280163380.6864746850615110.769074226998711
DMSO vs. DISU-0.03610944462621050.8824345527040140.987443803738299
DMSO vs. IL7-0.03778767906232140.8340802154316610.963494783989913
DMSO vs. SAHA0.1526808143969720.5181443892583670.822514650359474
HIV vs. Mock in Activation0.1420244890110840.8194876814485180.999983755607037
HIV vs. Mock in Latency0.0303131840021140.8547286636757270.999834320637052
IL7 vs. CD3-0.1552087959620490.6294588937989810.741129708609797
SAHA vs. CD30.01750030050984980.9604693955831470.973518549329972
SAHA vs. IL70.2008670421998650.4110835583141460.656671636810115
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) TRUE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.586839 0.000580925
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
1.058 1.009 1.104 1.193 0.989
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04330 Notch signaling pathway - Homo sapiens (human)