Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0002012
UniProt IDQ9H1E3
Primary gene name(s)NUCKS1
Synonym gene name(s)NUCKS
Protein nameNuclear ubiquitous casein and cyclin-dependent kinase substrate 1
Protein functionunknown
Subcellular locationNucleus.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q9H1E3
Gene Ontology
(Biological Process)
Complete annatation
cellular glucose homeostasis [GO:0001678];
cellular response to X-ray [GO:0071481];
chromatin organization [GO:0006325];
double-strand break repair via homologous recombination [GO:0000724];
gene conversion [GO:0035822];
interstrand cross-link repair [GO:0036297];
modulation by host of RNA binding by virus [GO:1990968];
modulation by host of viral RNA-binding transcription factor activity [GO:1990969];
positive regulation by host of viral genome replication [GO:0044829];
positive regulation by host of viral transcription [GO:0043923];
positive regulation of insulin receptor signaling pathway [GO:0046628];
regulation of DNA replication [GO:0006275];
regulation of DNA strand elongation [GO:0060382];
regulation of insulin receptor signaling pathway [GO:0046626];
regulation of transcription from RNA polymerase II promoter [GO:0006357];
release from viral latency [GO:0019046];
replication fork processing [GO:0031297]
Gene Ontology
(Molecular Function)
Complete annatation
poly(A RNA binding [GO:0044822];
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding [GO:0001077]
Gene Ontology
(Cellular Component)
Complete annatation
cytoplasm [GO:0005737];
nucleus [GO:0005634]
Protein-protein interaction122238
Phylogenetic treeQ9H1E3
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
      unknown
Brass et al., Science, 2008
      unknown
Smith et al., J. Immunol, 2010
      unknown
Interferon-stimulated
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model


DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD30.7326522260366440.02572822816581610.0573048676239997
AZA vs. DISU-0.2476664867276750.3290167843550440.878151994699947
AZA vs. IL70.02457310603511270.8980179264913360.999311006273513
AZA vs. SAHA-0.1918993191430180.4319945072911680.781285586706935
DISU vs. CD3-0.9921396378632550.006906375741130510.0213115062275949
DISU vs. IL70.2633119538232290.3032374569694370.686697148051504
DISU vs. SAHA0.05572413580004250.8480834062864860.959699799550203
DMSO vs. AZA-0.148194994554460.3748360927133331
DMSO vs. CD3-0.8921771802232720.00553473190240350.0149535036064757
DMSO vs. DISU0.09746905163598350.690561653407090.957954410639349
DMSO vs. IL70.1800377028628230.315609944046940.796743000788074
DMSO vs. SAHA-0.05152033270707260.8272466794141020.953054742228057
HIV vs. Mock in Activation-0.1649787653420560.7916809992859720.999983755607037
HIV vs. Mock in Latency0.03713352355250720.8213888886814160.999834320637052
IL7 vs. CD3-0.6989844373338710.03009918790578610.072916274397929
SAHA vs. CD3-0.9503175767353420.007763759728353860.0207336273447267
SAHA vs. IL7-0.2208735230515760.3642853561016970.615507606383614
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) FALSE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.0889572 0.594607
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
0.939 0.885 0.879 0.728 0.987
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Tat enhanced by 25116364
capsid stimulated by 25116364
Tat interacts with 25116364

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
not found
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