Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0002010
UniProt IDO95631
Primary gene name(s)NTN1
Synonym gene name(s)NTN1L
Protein nameNetrin-1
Protein functionNetrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating apoptosis. {ECO:0000269|PubMed:15343335}.
Subcellular locationSecreted, extracellular space, extracellular matrix {ECO:0000250}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: O95631
Gene Ontology
(Biological Process)
Complete annatation
anterior/posterior axon guidance [GO:0033564];
apoptotic process [GO:0006915];
axon guidance [GO:0007411];
Cdc42 protein signal transduction [GO:0032488];
establishment of nucleus localization [GO:0040023];
inner ear morphogenesis [GO:0042472];
mammary gland duct morphogenesis [GO:0060603];
negative regulation of axon extension [GO:0030517];
neuron migration [GO:0001764];
positive regulation of axon extension [GO:0045773];
positive regulation of cell motility [GO:2000147];
positive regulation of cell proliferation [GO:0008284];
Ras protein signal transduction [GO:0007265];
regulation of cell migration [GO:0030334];
single organismal cell-cell adhesion [GO:0016337];
substrate-dependent cell migration, cell extension [GO:0006930]
Gene Ontology
(Molecular Function)
Complete annatation
Gene Ontology
(Cellular Component)
Complete annatation
basement membrane [GO:0005604];
cytoplasm [GO:0005737];
extracellular region [GO:0005576]
Protein-protein interaction114816
Phylogenetic treeO95631
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD30.6766281019014940.0694543566817990.130428116609528
AZA vs. DISU-0.206692184668340.6903701778921020.968313969505284
AZA vs. IL7-0.3410007913494790.3361949039819670.999311006273513
AZA vs. SAHA-0.1599296382404640.6536808867707070.894689461663588
DISU vs. CD3-0.9034522441701640.07615701195743070.150595670765619
DISU vs. IL7-0.1394466229751280.7721737514369050.946588786123503
DISU vs. SAHA0.05153085567661610.9143234903394780.980696699374157
DMSO vs. AZA-0.01227092877414270.97903167830851
DMSO vs. CD3-0.7096292685070750.1020426429772720.173742361714806
DMSO vs. DISU0.1921810571511070.7300203504358840.966052571221353
DMSO vs. IL7-0.3174566318076810.4466743685729090.867967476478598
DMSO vs. SAHA-0.1519707952641690.714861211481310.914948418387652
HIV vs. Mock in Activation-0.02823577424560380.9657058055985890.999983755607037
HIV vs. Mock in Latency0.304739261840650.552278103310610.999834320637052
IL7 vs. CD3-1.020675416258420.004944197939237840.0166051460646462
SAHA vs. CD3-0.8644110125312610.02815886572021220.0614293726698897
SAHA vs. IL70.1778894060038560.5634257712843190.772172508743366
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
-1.8 0.005204179 -1.6 0.010876391 -1.9 0.062159196
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) TRUE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
4URT X-ray 3.1Å A=39-453.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
HIV-1 virus replication enhanced by expression of human gene 18854154

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04360 Axon guidance - Homo sapiens (human)