Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0002003
UniProt IDQ9UHY1
Primary gene name(s)NRBP1
Synonym gene name(s)BCON3, NRBP
Protein nameNuclear receptor-binding protein
Protein functionMay play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases. Binding to the NS3 protein of dengue virus type 2 appears to subvert this activity into the alteration of the intracellular membrane structure associated with flaviviral replication. {ECO:0000269|PubMed:11956649, ECO:0000269|PubMed:15084397, ECO:0000303|PubMed:11956649}.
Subcellular locationCytoplasm, cell cortex {ECO:0000269|PubMed:11956649}. Endomembrane system {ECO:0000269|PubMed:11956649}. Cell projection, lamellipodium {ECO:0000269|PubMed:11956649}. Note=Colocalizes with activated RAC3 to endomembranes and at the cell periphery in lamellipodia.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q9UHY1
Gene Ontology
(Biological Process)
Complete annatation
ER to Golgi vesicle-mediated transport [GO:0006888];
intracellular signal transduction [GO:0035556];
protein phosphorylation [GO:0006468];
transcription initiation from RNA polymerase II promoter [GO:0006367]
Gene Ontology
(Molecular Function)
Complete annatation
ATP binding [GO:0005524];
protein homodimerization activity [GO:0042803];
protein serine/threonine kinase activity [GO:0004674]
Gene Ontology
(Cellular Component)
Complete annatation
cell cortex [GO:0005938];
cytosol [GO:0005829];
endomembrane system [GO:0012505];
lamellipodium [GO:0030027];
membrane [GO:0016020];
nucleoplasm [GO:0005654];
perinuclear region of cytoplasm [GO:0048471]
Protein-protein interaction118995
Phylogenetic treeQ9UHY1
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
      Yes - Two siRNA pools inhibit HIV replication and inhibition of Tat-mediated transactivation of the HIV LTR is not observed
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD30.7513565036352940.02235488750358770.0510195130911681
AZA vs. DISU0.3041937256381490.2298423576245540.816706641605109
AZA vs. IL7-0.07719507141903180.6879127901531630.999311006273513
AZA vs. SAHA-0.2670579953563960.2736987884783530.648164396895634
DISU vs. CD3-0.4598415224018590.2067672569921830.327008245473323
DISU vs. IL7-0.390759526254920.1217098771117750.456866632833668
DISU vs. SAHA-0.5689090957943060.05167025224159930.284828958132093
DMSO vs. AZA0.01347063411209930.9358843937635871
DMSO vs. CD3-0.7506338460690360.01942513918118540.0437559392590547
DMSO vs. DISU-0.292882332440850.230811341685430.744823751434569
DMSO vs. IL7-0.08319425539090820.6434484678059270.923316916281805
DMSO vs. SAHA-0.2856293537203610.2257682498010450.572146173322944
HIV vs. Mock in Activation0.01945142959752240.9750253707407190.999983755607037
HIV vs. Mock in Latency0.07237038542923420.6608244167586320.999834320637052
IL7 vs. CD3-0.8222734698077340.0109211917080390.032120023924931
SAHA vs. CD3-1.041731733068380.003499952769108530.0104796916809985
SAHA vs. IL7-0.1923860244086640.4294028577646410.670855262301655
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) TRUE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.166005 0.280727
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
0.98 0.962 0.996 0.983 0.968
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
HIV-1 virus replication enhanced by expression of human gene 18976975
Pr55(Gag) interacts with 24447338

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
not found