Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0001999
UniProt IDP49116
Primary gene name(s)NR2C2
Synonym gene name(s)TAK1, TR4
Protein nameNuclear receptor subfamily 2 group C member 2
Protein functionOrphan nuclear receptor that can act as a repressor or activator of transcription. An important repressor of nuclear receptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways. May regulate gene expression during the late phase of spermatogenesis. Together with NR2C1, forms the core of the DRED, direct repeat erythroid-definitive complex that represses embryonic and fetal globin transcription including that of GATA1. Binds to hormone response elements, HREs consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Plays a fundamental role in early embryonic development and embryonic stem cells. Required for normal spermatogenesis and cerebellum development. Appears to be important for neurodevelopmentally regulated behavior, By similarity. Activates transcriptional activity of LHCG. Antagonist of PPARA-mediated transactivation. {ECO:0000250, ECO:0000269|PubMed:10347174, ECO:0000269|PubMed:10644740, ECO:0000269|PubMed:17974920, ECO:0000269|PubMed:7779113, ECO:0000269|PubMed:9556573}.
Subcellular locationNucleus {ECO:0000255|PROSITE-ProRule:PRU00407, ECO:0000269|PubMed:10644740, ECO:0000269|PubMed:15302918}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P49116
Gene Ontology
(Biological Process)
Complete annatation
cell differentiation [GO:0030154];
cerebellum development [GO:0021549];
meiotic cell cycle [GO:0051321];
nervous system development [GO:0007399];
p38MAPK cascade [GO:0038066];
positive regulation of behavior [GO:0048520];
positive regulation of embryonic development [GO:0040019];
positive regulation of myoblast differentiation [GO:0045663];
positive regulation of transcription from RNA polymerase II promoter [GO:0045944];
regulation of transcription, DNA-templated [GO:0006355];
spermatogenesis [GO:0007283];
transcription initiation from RNA polymerase II promoter [GO:0006367]
Gene Ontology
(Molecular Function)
Complete annatation
protein heterodimerization activity [GO:0046982];
receptor activity [GO:0004872];
sequence-specific DNA binding [GO:0043565];
steroid hormone receptor activity [GO:0003707];
transcription coactivator activity [GO:0003713];
transcription factor activity, sequence-specific DNA binding [GO:0003700];
zinc ion binding [GO:0008270]
Gene Ontology
(Cellular Component)
Complete annatation
nucleoplasm [GO:0005654]
Protein-protein interaction113034
Phylogenetic treeP49116
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-0.4269152234319980.1945419240004350.298831622353706
AZA vs. DISU0.4302444408429890.0910846348247620.622680215201834
AZA vs. IL7-0.09414297036844450.6275341520639140.999311006273513
AZA vs. SAHA0.05272677822134620.8302614440098170.959693352273903
DISU vs. CD30.8439943586267940.02161470691482360.0548980778490397
DISU vs. IL7-0.5332955319267370.03537735736882540.246203175142892
DISU vs. SAHA-0.3759887717033310.1983758409328210.569796512044702
DMSO vs. AZA0.04262293086660620.8014060354677521
DMSO vs. CD30.4583521125519140.1538740859557720.24215116524848
DMSO vs. DISU-0.3894907426430410.1125526714092140.588455151470561
DMSO vs. IL7-0.1294503998695530.4757089278987820.880353467259539
DMSO vs. SAHA0.00329088474117810.9889456404695460.996342259020082
HIV vs. Mock in Activation0.43339144957740.4948203247992020.999983755607037
HIV vs. Mock in Latency0.08129108307686660.624988542471690.999834320637052
IL7 vs. CD30.3398195874768840.2932436336900410.43093119729063
SAHA vs. CD30.4548429173207280.2032864675983990.305912648078054
SAHA vs. IL70.1428646046270490.5598172836187350.769703776712027
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) TRUE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.402972 0.150776
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
0.974 0.891 0.803 0.8 0.892
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
3P0U X-ray 3.0Å A/B=348-596.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
not found