Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0001968
UniProt IDQ13287
Primary gene name(s)NMI
Synonym gene name(s)unknown
Protein nameN-myc-interactor
Protein functionMay be involved in augmenting coactivator protein recruitment to a group of sequence-specific transcription factors. Augments cytokine-mediated STAT transcription. Enhances CBP/p300 coactivator protein recruitment to STAT1 and STAT5.
Subcellular locationCytoplasm.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q13287
Gene Ontology
(Biological Process)
Complete annatation
inflammatory response [GO:0006954];
interferon-gamma-mediated signaling pathway [GO:0060333];
JAK-STAT cascade [GO:0007259];
negative regulation of innate immune response [GO:0045824];
negative regulation of interferon-alpha biosynthetic process [GO:0045355];
negative regulation of interferon-beta biosynthetic process [GO:0045358];
positive regulation of protein K48-linked ubiquitination [GO:1902524];
transcription from RNA polymerase II promoter [GO:0006366]
Gene Ontology
(Molecular Function)
Complete annatation
transcription cofactor activity [GO:0003712]
Gene Ontology
(Cellular Component)
Complete annatation
cytoplasm [GO:0005737];
nucleoplasm [GO:0005654]
Protein-protein interaction114561
Phylogenetic treeQ13287
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
      unknown
Brass et al., Science, 2008
      unknown
Smith et al., J. Immunol, 2010
      unknown
Interferon-stimulated
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: 4.505183908; Folds changes 16h: 3.072708695; Tested: tested;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model


DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD31.094618447898990.001012155919759230.00367595518617135
AZA vs. DISU0.4075081379150030.1093027298301020.655381602807861
AZA vs. IL70.2643518268471510.1736610682586430.941150532286992
AZA vs. SAHA-0.8686117071393490.0005181171873894770.013126215937326
DISU vs. CD3-0.6996510341853480.05621491870909530.118614737488928
DISU vs. IL7-0.1518830307780890.5482122918402480.852692973534022
DISU vs. SAHA-1.275554707060872.17538113689297e-050.00117509566717254
DMSO vs. AZA-0.1523848787634740.3710414500771981
DMSO vs. CD3-1.257109649473180.0001176082096094880.000520037475129713
DMSO vs. DISU-0.5613263853385540.02242012613376950.307233904729923
DMSO vs. IL70.4236228523487490.02001874430309140.289618589605664
DMSO vs. SAHA-0.7239278857512490.002725842830094140.0362377032639125
HIV vs. Mock in Activation-0.2239321685403360.7192396552356280.999983755607037
HIV vs. Mock in Latency0.04939291914330070.7676361383594460.999834320637052
IL7 vs. CD3-0.8211832970842540.01135703796929320.0330983436409816
SAHA vs. CD3-1.988568717586015.97832067184001e-086.64895147783239e-07
SAHA vs. IL7-1.137251394071845.36672163542473e-060.000185545784248606
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
1.9 0.000134133 1.3 0.000395284 1.6 0.019010706
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) FALSE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.523799 0.000305467
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
0.892 0.94 0.887 0.996 0.772
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
203964_at 1.62 No upregulated in CD8+ cells

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Tat downregulates 18051367

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
not found
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