Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0001962
UniProt IDQ9NZ94
Primary gene name(s)NLGN3
Synonym gene name(s)KIAA1480, NL3
Protein nameNeuroligin-3
Protein functionCell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and may mediate its effects by clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. May also play a role in glia-glia or glia-neuron interactions in the developing peripheral nervous system, By similarity. {ECO:0000250, ECO:0000269|PubMed:15620359}.
Subcellular locationCell membrane {ECO:0000250};
Single-pass type I membrane protein {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Note=Detected at both glutamatergic and GABAergic synapses. {ECO:0000250}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q9NZ94
Gene Ontology
(Biological Process)
Complete annatation
adult behavior [GO:0030534];
axon extension [GO:0048675];
excitatory postsynaptic potential [GO:0060079];
inhibitory postsynaptic potential [GO:0060080];
learning [GO:0007612];
long-term synaptic potentiation [GO:0060291];
modulation of synaptic transmission [GO:0050804];
negative regulation of dendritic spine morphogenesis [GO:0061002];
negative regulation of excitatory postsynaptic potential [GO:0090394];
neuron cell-cell adhesion [GO:0007158];
oligodendrocyte differentiation [GO:0048709];
positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [GO:2000969];
positive regulation of excitatory postsynaptic potential [GO:2000463];
positive regulation of synapse assembly [GO:0051965];
positive regulation of synaptic transmission, glutamatergic [GO:0051968];
positive regulation of synaptic vesicle clustering [GO:2000809];
postsynaptic membrane assembly [GO:0097104];
presynaptic membrane assembly [GO:0097105];
receptor-mediated endocytosis [GO:0006898];
regulation of long-term synaptic potentiation [GO:1900271];
regulation of N-methyl-D-aspartate selective glutamate receptor activity [GO:2000310];
regulation of respiratory gaseous exchange by neurological system process [GO:0002087];
regulation of terminal button organization [GO:2000331];
rhythmic synaptic transmission [GO:0060024];
social behavior [GO:0035176];
synapse assembly [GO:0007416];
synapse organization [GO:0050808];
visual learning [GO:0008542];
vocalization behavior [GO:0071625]
Gene Ontology
(Molecular Function)
Complete annatation
carboxylic ester hydrolase activity [GO:0052689];
cell adhesion molecule binding [GO:0050839];
neurexin family protein binding [GO:0042043];
receptor activity [GO:0004872];
scaffold protein binding [GO:0097110]
Gene Ontology
(Cellular Component)
Complete annatation
cell junction [GO:0030054];
cell surface [GO:0009986];
dendrite [GO:0030425];
endocytic vesicle [GO:0030139];
excitatory synapse [GO:0060076];
inhibitory synapse [GO:0060077];
integral component of plasma membrane [GO:0005887];
neuronal cell body [GO:0043025];
postsynapse [GO:0098794];
synapse [GO:0045202]
Protein-protein interaction119944
Phylogenetic treeQ9NZ94
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
      Yes - Two siRNA pools inhibit HIV replication and inhibition of Tat-mediated transactivation of the HIV LTR is not observed
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-0.4540895322250520.3847235489468010.506458764167703
AZA vs. DISU0.4973380503456970.06362447272468130.555663558430965
AZA vs. IL7-0.1922390216250350.3717000360698130.999311006273513
AZA vs. SAHA0.2459733990733090.3446869076485230.716762373554123
DISU vs. CD30.9356592530535510.09978023528545220.18617245534013
DISU vs. IL7-0.6972067000339830.009465624638826830.113518978447638
DISU vs. SAHA-0.2486607641768550.4143053888417280.770008202643197
DMSO vs. AZA0.08386436378431360.662250276367581
DMSO vs. CD30.5236316019452650.3209797304046780.433877042489589
DMSO vs. DISU-0.4162120290647970.105190992542540.578339386215277
DMSO vs. IL7-0.2661113050695910.1873124209203690.699117292739433
DMSO vs. SAHA0.1575388066201970.5299991988642540.82903488885196
HIV vs. Mock in Activation0.1203370381612660.9147367079498720.999983755607037
HIV vs. Mock in Latency-0.1397641337983760.4423518616451350.999834320637052
IL7 vs. CD30.2640299706433440.6124570311124360.727123883897114
SAHA vs. CD30.6757721066076530.1921535988117270.292648280352978
SAHA vs. IL70.4368584179412220.09263533303992730.274987201702218
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) TRUE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.0486227 0.906
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
HIV-1 virus replication enhanced by expression of human gene 18976975

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04514 Cell adhesion molecules (CAMs) - Homo sapiens (human)