Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0001933
UniProt IDQ99519
Primary gene name(s)NEU1
Synonym gene name(s)NANH
Protein nameSialidase-1
Protein functionCatalyzes the removal of sialic acid, N-acetylneuraminic acid moities from glycoproteins and glycolipids. To be active, it is strictly dependent on its presence in the multienzyme complex. Appears to have a preference for alpha 2-3 and alpha 2-6 sialyl linkage. {ECO:0000269|PubMed:8985184}.
Subcellular locationLysosome membrane;
Peripheral membrane protein;
Lumenal side. Lysosome lumen. Cell membrane. Cytoplasmic vesicle. Note=Localized not only on the inner side of the lysosomal membrane and in the lysosomal lumen, but also on the plasma membrane and in intracellular vesicles.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q99519
Gene Ontology
(Biological Process)
Complete annatation
ganglioside catabolic process [GO:0006689];
glycosphingolipid metabolic process [GO:0006687];
oligosaccharide catabolic process [GO:0009313]
Gene Ontology
(Molecular Function)
Complete annatation
exo-alpha-(2->3-sialidase activity [GO:0052794];
exo-alpha-(2->6-sialidase activity [GO:0052795];
exo-alpha-(2->8-sialidase activity [GO:0052796];
exo-alpha-sialidase activity [GO:0004308]
Gene Ontology
(Cellular Component)
Complete annatation
cell junction [GO:0030054];
cell surface [GO:0009986];
cytoplasmic, membrane-bounded vesicle [GO:0016023];
extracellular exosome [GO:0070062];
intracellular membrane-bounded organelle [GO:0043231];
lysosomal lumen [GO:0043202];
lysosomal membrane [GO:0005765];
lysosome [GO:0005764];
membrane [GO:0016020];
plasma membrane [GO:0005886]
Protein-protein interaction110831
Phylogenetic treeQ99519
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-0.8181721281902480.01362284229251590.0338929480080553
AZA vs. DISU0.6027627046419130.01798663124901550.318977034644305
AZA vs. IL7-0.1807328771013360.352011448586610.999311006273513
AZA vs. SAHA-0.3191564311555970.1949554342609250.562011515786801
DISU vs. CD31.407705575832650.000156492055176760.000838592690982752
DISU vs. IL7-0.7930789575243150.00182211902861840.0400414640764174
DISU vs. SAHA-0.9191477424944340.001903864258638980.0326058389113046
DMSO vs. AZA-0.01747112220915950.9179751734981181
DMSO vs. CD30.788009161636150.01497282352292270.0350652952618029
DMSO vs. DISU-0.6224586654598470.01129882299587910.226391849753808
DMSO vs. IL7-0.1557423118087580.3913479570581230.840634148283159
DMSO vs. SAHA-0.3064630063161960.1979145317643930.536759026133017
HIV vs. Mock in Activation-0.09538491913263730.8785989253004970.999983755607037
HIV vs. Mock in Latency0.1209123810056070.4697702434968230.999834320637052
IL7 vs. CD30.6430429129289230.04772413791105490.105630826833088
SAHA vs. CD30.4756573922043740.1804122729081770.278994460493598
SAHA vs. IL7-0.1406000048750910.5671605715679990.774808108540083
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) TRUE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.131542 0.38811
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
1.019 1.17 1.331 1.298 1.179
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

Drugbank ID Drug Name Drug Status Pharmacological Action Drug Action
DB00198 Oseltamivir approved unknown inhibitor

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Envelope surface glycoprotein gp120 processed by 12487819
HIV-1 virus replication enhanced by expression of human gene 19460752

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa00511 Other glycan degradation - Homo sapiens (human)
hsa00600 Sphingolipid metabolism - Homo sapiens (human)
hsa04142 Lysosome - Homo sapiens (human)