Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0001909
UniProt IDQ15021
Primary gene name(s)NCAPD2
Synonym gene name(s)CAPD2, CNAP1, KIAA0159
Protein nameCondensin complex subunit 1
Protein functionRegulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain. {ECO:0000269|PubMed:11136719}.
Subcellular locationNucleus {ECO:0000269|PubMed:10958694}. Cytoplasm {ECO:0000269|PubMed:10958694}. Chromosome {ECO:0000269|PubMed:10958694}. Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDK1, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q15021
Gene Ontology
(Biological Process)
Complete annatation
cell division [GO:0051301];
chromosome separation [GO:0051304];
meiotic chromosome condensation [GO:0010032];
mitotic chromosome condensation [GO:0007076]
Gene Ontology
(Molecular Function)
Complete annatation
chromatin binding [GO:0003682];
histone binding [GO:0042393]
Gene Ontology
(Cellular Component)
Complete annatation
condensed chromosome [GO:0000793];
condensed chromosome, centromeric region [GO:0000779];
condensin complex [GO:0000796];
condensin core heterodimer [GO:0000797];
cytoplasm [GO:0005737];
cytosol [GO:0005829];
membrane [GO:0016020];
nuclear condensin complex [GO:0000799];
nucleoplasm [GO:0005654];
nucleus [GO:0005634]
Protein-protein interaction115246
Phylogenetic treeQ15021
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
      unknown
Brass et al., Science, 2008
      unknown
Smith et al., J. Immunol, 2010
      unknown
Interferon-stimulated
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model


DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-1.091440569964360.03776321655014720.0789194675324209
AZA vs. DISU0.05101741439076090.8400679396825560.986800805932004
AZA vs. IL7-0.03741978228856410.8460232587078290.999311006273513
AZA vs. SAHA0.2171492215574750.3743596239975680.740388935314735
DISU vs. CD31.1306072735070.03415871926829030.0795717098207708
DISU vs. IL7-0.09815866694263720.6979287349579150.922418222091218
DISU vs. SAHA0.1681111220936110.5639868944922440.858050321713367
DMSO vs. AZA0.04146674950680960.8044795129419641
DMSO vs. CD31.120880103630410.03243655513024410.0669117763983469
DMSO vs. DISU-0.01172317084468130.9616686974801630.994294013509907
DMSO vs. IL7-0.07151857511325370.6911893808029150.936954851917814
DMSO vs. SAHA0.1701036172449650.471878247530680.797331847246202
HIV vs. Mock in Activation0.1017744719394670.9288591437279890.999983755607037
HIV vs. Mock in Latency0.03791290003270910.8182307008563290.999834320637052
IL7 vs. CD31.060469351855530.04659275341815460.103592941078499
SAHA vs. CD31.284590733704550.01970487889625990.0455031408423136
SAHA vs. IL70.2520251006815720.3057708977651880.554322370765176
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) FALSE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.0915108 0.572474
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
1.004 1.032 1.09 1.071 1.104
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Tat interacts with 19454010

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
not found
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