Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0001895
UniProt IDQ8WY41
Primary gene name(s)NANOS1
Synonym gene name(s)NOS1
Protein nameNanos homolog 1
Protein functionMay act as a translational repressor which regulates translation of specific mRNAs by forming a complex with PUM2 that associates with the 3'-UTR of mRNA targets. Capable of interfering with the proadhesive and anti-invasive functions of E-cadherin. Up-regulates the production of MMP14 to promote tumor cell invasion. {ECO:0000269|PubMed:17047063, ECO:0000269|PubMed:18223680}.
Subcellular locationCytoplasm, perinuclear region {ECO:0000269|PubMed:12690449, ECO:0000269|PubMed:17047063, ECO:0000269|PubMed:19168546}. Cytoplasm {ECO:0000269|PubMed:12690449, ECO:0000269|PubMed:17047063, ECO:0000269|PubMed:19168546}. Note=Colocalizes with SNAPIN and PUM2 in the perinuclear region of germ cells. {ECO:0000269|PubMed:12690449, ECO:0000269|PubMed:19168546}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q8WY41
Gene Ontology
(Biological Process)
Complete annatation
cell migration [GO:0016477];
cerebellar neuron development [GO:0098749];
epithelial cell migration [GO:0010631];
negative regulation of translation [GO:0017148];
positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153];
posttranscriptional regulation of gene expression [GO:0010608];
regulation of cell growth [GO:0001558];
tissue homeostasis [GO:0001894]
Gene Ontology
(Molecular Function)
Complete annatation
RNA binding [GO:0003723];
translation repressor activity [GO:0030371];
zinc ion binding [GO:0008270]
Gene Ontology
(Cellular Component)
Complete annatation
cytoplasm [GO:0005737];
perinuclear region of cytoplasm [GO:0048471]
Protein-protein interaction131092
Phylogenetic treeQ8WY41
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD30.6210212498177650.06320355407783620.120827494553672
AZA vs. DISU-0.4976228155084810.05985293617248680.544833557655711
AZA vs. IL70.1853882477560110.3636878012288530.999311006273513
AZA vs. SAHA-0.1585136859241930.5337946640964390.839893324787914
DISU vs. CD3-1.131440446176370.00231722936248990.00848843630866897
DISU vs. IL70.6738590404129940.01037213088953740.119999902655239
DISU vs. SAHA0.3404417648791410.2586039170255350.636721404511744
DMSO vs. AZA-0.09462562834148250.6046711669419431
DMSO vs. CD3-0.7271404838243760.02592576939115790.0555894841841437
DMSO vs. DISU0.4013727189806990.1153624817177070.59136370451859
DMSO vs. IL70.2865653648323450.135114341762930.632510713117988
DMSO vs. SAHA-0.07081911951271840.7735161750586910.936132841428534
HIV vs. Mock in Activation-0.03409327844584880.9568576774625420.999983755607037
HIV vs. Mock in Latency-0.05657466346445830.7518862400474410.999834320637052
IL7 vs. CD3-0.4272798516625310.1921143083762790.312748565736651
SAHA vs. CD3-0.8041329860912160.02578589101933740.0570203048659449
SAHA vs. IL7-0.3475323589342220.169921842887530.394436525587293
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) FALSE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.0254221 0.915494
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
4CQO X-ray 2.8Å B/D=40-56.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
not found