Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0001877
UniProt IDP01106
Primary gene name(s)MYC
Synonym gene name(s)BHLHE39
Protein nameMyc proto-oncogene protein
Protein functionTranscription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.
Subcellular locationNucleus, nucleoplasm {ECO:0000269|PubMed:17558397}. Nucleus, nucleolus {ECO:0000269|PubMed:17558397}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P01106
Gene Ontology
(Biological Process)
Complete annatation
beta-catenin-TCF complex assembly [GO:1904837];
branching involved in ureteric bud morphogenesis [GO:0001658];
canonical Wnt signaling pathway [GO:0060070];
cell cycle arrest [GO:0007050];
cellular iron ion homeostasis [GO:0006879];
cellular response to DNA damage stimulus [GO:0006974];
cellular response to drug [GO:0035690];
cellular response to UV [GO:0034644];
chromatin remodeling [GO:0006338];
chromosome organization [GO:0051276];
energy reserve metabolic process [GO:0006112];
fibroblast apoptotic process [GO:0044346];
MAPK cascade [GO:0000165];
negative regulation of apoptotic process [GO:0043066];
negative regulation of cell division [GO:0051782];
negative regulation of fibroblast proliferation [GO:0048147];
negative regulation of monocyte differentiation [GO:0045656];
negative regulation of stress-activated MAPK cascade [GO:0032873];
negative regulation of transcription from RNA polymerase II promoter [GO:0000122];
Notch signaling pathway [GO:0007219];
oxygen transport [GO:0015671];
positive regulation of cell proliferation [GO:0008284];
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280];
positive regulation of DNA biosynthetic process [GO:2000573];
positive regulation of epithelial cell proliferation [GO:0050679];
positive regulation of fibroblast proliferation [GO:0048146];
positive regulation of gene expression [GO:0010628];
positive regulation of mesenchymal cell proliferation [GO:0002053];
positive regulation of metanephric cap mesenchymal cell proliferation [GO:0090096];
positive regulation of response to DNA damage stimulus [GO:2001022];
positive regulation of telomerase activity [GO:0051973];
positive regulation of transcription, DNA-templated [GO:0045893];
positive regulation of transcription from RNA polymerase II promoter [GO:0045944];
regulation of gene expression [GO:0010468];
regulation of telomere maintenance [GO:0032204];
response to drug [GO:0042493];
response to gamma radiation [GO:0010332];
response to growth factor [GO:0070848]
Gene Ontology
(Molecular Function)
Complete annatation
DNA binding [GO:0003677];
E-box binding [GO:0070888];
protein complex binding [GO:0032403];
repressing transcription factor binding [GO:0070491];
RNA polymerase II core promoter proximal region sequence-specific DNA binding [GO:0000978];
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding [GO:0001077];
transcription factor activity, sequence-specific DNA binding [GO:0003700];
transcription factor binding [GO:0008134]
Gene Ontology
(Cellular Component)
Complete annatation
cytosol [GO:0005829];
nucleolus [GO:0005730];
nucleoplasm [GO:0005654];
nucleus [GO:0005634];
protein complex [GO:0043234]
Protein-protein interaction110694
Phylogenetic treeP01106
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD31.743795848623862.29184600852861e-072.03912060451849e-06
AZA vs. DISU-0.424197921113630.09465137478014310.629844344006878
AZA vs. IL70.3195100099428620.09628588147472150.825080779686457
AZA vs. SAHA-0.7062435242477010.03083070586052750.202678613232268
DISU vs. CD3-2.180312147175397.78465347739399e-091.24106436742357e-07
DISU vs. IL70.7347448731007160.003841124896657220.0636318217770413
DISU vs. SAHA-0.2804116071787620.4744430203644960.806526867153655
DMSO vs. AZA0.05798796489433060.7288646081475841
DMSO vs. CD3-1.701715207816772.43255066423309e-071.95760554255724e-06
DMSO vs. DISU0.4791013192188860.05114034741521390.445067187377236
DMSO vs. IL70.2694318404908030.133448710133440.632122723648975
DMSO vs. SAHA-0.7691711560250640.01840116431125380.134427507190939
HIV vs. Mock in Activation0.1543803661746190.8055639791125880.999983755607037
HIV vs. Mock in Latency0.005761302988584090.9761969859220210.999834320637052
IL7 vs. CD3-1.416505724599151.61227443745693e-050.000117286740327164
SAHA vs. CD3-2.473411614322762.6988640211556e-094.10412520674217e-08
SAHA vs. IL7-1.028876865854870.001442376634771650.0155129736440443
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change -1.52709725
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
1.7 0.001705754 1.2 0.188728961 1.2 0.371483177
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) FALSE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.413159 0.00674641
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
1.044 0.89 0.801 0.911 1.005
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

Drugbank ID Drug Name Drug Status Pharmacological Action Drug Action
DB08813 Nadroparin approved unknown inhibitor

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
1A93 NMR - A=406-434.
1EE4 X-ray 2.1Å C/D/E/F=320-328.
1MV0 NMR - A=55-68.
1NKP X-ray 1.8Å A/D=353-434.
2A93 NMR - A=406-434.
2OR9 X-ray 2.7Å P=410-419.
4Y7R X-ray 1.9Å B=260-267.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Tat associates with 19818711
Envelope surface glycoprotein gp120 downregulates 11208609
matrix induces phosphorylation of 20402410
Tat inhibited by 17670825
Tat upregulates 1318011

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04010 MAPK signaling pathway - Homo sapiens (human)
hsa04012 ErbB signaling pathway - Homo sapiens (human)
hsa04110 Cell cycle - Homo sapiens (human)
hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
hsa04310 Wnt signaling pathway - Homo sapiens (human)
hsa04350 TGF-beta signaling pathway - Homo sapiens (human)
hsa04390 Hippo signaling pathway - Homo sapiens (human)
hsa04550 Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)
hsa04630 Jak-STAT signaling pathway - Homo sapiens (human)
hsa04919 Thyroid hormone signaling pathway - Homo sapiens (human)
hsa05161 Hepatitis B - Homo sapiens (human)
hsa05166 HTLV-I infection - Homo sapiens (human)
hsa05169 Epstein-Barr virus infection - Homo sapiens (human)
hsa05200 Pathways in cancer - Homo sapiens (human)
hsa05202 Transcriptional misregulation in cancer - Homo sapiens (human)
hsa05205 Proteoglycans in cancer - Homo sapiens (human)
hsa05206 MicroRNAs in cancer - Homo sapiens (human)
hsa05210 Colorectal cancer - Homo sapiens (human)
hsa05213 Endometrial cancer - Homo sapiens (human)
hsa05216 Thyroid cancer - Homo sapiens (human)
hsa05219 Bladder cancer - Homo sapiens (human)
hsa05220 Chronic myeloid leukemia - Homo sapiens (human)
hsa05221 Acute myeloid leukemia - Homo sapiens (human)
hsa05222 Small cell lung cancer - Homo sapiens (human)
hsa05224 Breast cancer - Homo sapiens (human)
hsa05230 Central carbon metabolism in cancer - Homo sapiens (human)