Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0001875
UniProt IDQ9BQG0
Primary gene name(s)MYBBP1A
Synonym gene name(s)P160
Protein nameMyb-binding protein 1A
Protein functionMay activate or repress transcription via interactions with sequence specific DNA-binding proteins. Repression may be mediated at least in part by histone deacetylase activity, HDAC activity. Acts as a corepressor and in concert with CRY1, represses the transcription of the core circadian clock component PER2. Preferentially binds to dimethylated histone H3 'Lys-9', H3K9me2 on the PER2 promoter. {ECO:0000250|UniProtKB:Q7TPV4}.
Subcellular locationCytoplasm {ECO:0000269|PubMed:12429849}. Nucleus {ECO:0000269|PubMed:12429849}. Nucleus, nucleolus {ECO:0000269|PubMed:12429849}. Note=Shuttles between the nucleus and cytoplasm. Nuclear import may be mediated by KPNA2, while export appears to depend partially on XPO1/CRM1, By similarity. Predominantly nucleolar. {ECO:0000250|UniProtKB:Q7TPV4}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q9BQG0
Gene Ontology
(Biological Process)
Complete annatation
cellular response to glucose starvation [GO:0042149];
circadian regulation of gene expression [GO:0032922];
intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332];
negative regulation of transcription, DNA-templated [GO:0045892];
nucleocytoplasmic transport [GO:0006913];
osteoblast differentiation [GO:0001649];
positive regulation of anoikis [GO:2000210];
positive regulation of cell cycle arrest [GO:0071158];
positive regulation of gene expression, epigenetic [GO:0045815];
regulation of transcription, DNA-templated [GO:0006355];
respiratory electron transport chain [GO:0022904];
transcription, DNA-templated [GO:0006351]
Gene Ontology
(Molecular Function)
Complete annatation
core promoter binding [GO:0001047];
DNA-directed DNA polymerase activity [GO:0003887];
poly(A RNA binding [GO:0044822];
sequence-specific DNA binding [GO:0043565];
transcription corepressor activity [GO:0003714];
transcription factor binding [GO:0008134]
Gene Ontology
(Cellular Component)
Complete annatation
cytoplasm [GO:0005737];
intracellular membrane-bounded organelle [GO:0043231];
membrane [GO:0016020];
NLS-dependent protein nuclear import complex [GO:0042564];
nucleolus [GO:0005730];
nucleoplasm [GO:0005654];
nucleus [GO:0005634]
Protein-protein interaction115770
Phylogenetic treeQ9BQG0
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD30.868949466056730.064180803483090.122354296748942
AZA vs. DISU-0.3968488978022210.1298629355666320.697811905660892
AZA vs. IL70.2703612057832240.1689724196488090.939962049460495
AZA vs. SAHA-0.4788995663584170.05121990714193640.274276689256678
DISU vs. CD3-1.278138850809270.01145698109107930.0324475212835724
DISU vs. IL70.6578514540450380.01398442576979650.144446537416647
DISU vs. SAHA-0.07961342526691850.7868078356693220.942381061064321
DMSO vs. AZA0.1435238737590330.392174606592871
DMSO vs. CD3-0.7377270456469030.1061309166209230.179345177666204
DMSO vs. DISU0.5383469968434590.02819008029235760.340677233364738
DMSO vs. IL70.1344242452613140.4548082904678390.871186147243034
DMSO vs. SAHA-0.6275427122914890.0081467545414210.0785036686021457
HIV vs. Mock in Activation0.2856016626525930.769675260039150.999983755607037
HIV vs. Mock in Latency-0.09602216353121540.5617241977742450.999834320637052
IL7 vs. CD3-0.5927388250886450.2032522842290290.32620260718221
SAHA vs. CD3-1.3709288454740.003865942622504280.0114459244245854
SAHA vs. IL7-0.7518010903221770.002221594173779540.0212105000534848
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change -1.335105681
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) FALSE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.626434 0.000305467
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
0.992 0.974 0.839 0.762 0.826
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Rev interacts with 22174317
Envelope surface glycoprotein gp120 complexes with 23125841
Gag-Pol complexes with 23125841
Pr55(Gag) complexes with 23125841
Nef complexes with 23125841

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
not found