Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0001851
UniProt IDP26038
Primary gene name(s)MSN
Synonym gene name(s)unknown
Protein nameMoesin
Protein functionProbably involved in connections of major cytoskeletal structures to the plasma membrane. May inhibit herpes simplex virus 1 infection at an early stage. {ECO:0000269|PubMed:21549406}.
Subcellular locationCell membrane {ECO:0000250};
Peripheral membrane protein {ECO:0000250};
Cytoplasmic side {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Apical cell membrane {ECO:0000250};
Peripheral membrane protein {ECO:0000250};
Cytoplasmic side {ECO:0000250}. Cell projection, microvillus membrane {ECO:0000250};
Peripheral membrane protein {ECO:0000250};
Cytoplasmic side {ECO:0000250}. Note=Phosphorylated form is enriched in microvilli-like structures at apical membrane, By similarity. Increased cell membrane localization of both phosphorylated and non-phosphorylated forms seen after thrombin treatment. {ECO:0000250, ECO:0000269|PubMed:18586956}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P26038
Gene Ontology
(Biological Process)
Complete annatation
cellular response to testosterone stimulus [GO:0071394];
establishment of endothelial barrier [GO:0061028];
establishment of epithelial cell apical/basal polarity [GO:0045198];
gland morphogenesis [GO:0022612];
leukocyte cell-cell adhesion [GO:0007159];
leukocyte migration [GO:0050900];
membrane to membrane docking [GO:0022614];
movement of cell or subcellular component [GO:0006928];
positive regulation of cellular protein catabolic process [GO:1903364];
positive regulation of early endosome to late endosome transport [GO:2000643];
positive regulation of gene expression [GO:0010628];
positive regulation of podosome assembly [GO:0071803];
positive regulation of protein localization to early endosome [GO:1902966];
regulation of cell shape [GO:0008360];
regulation of cell size [GO:0008361];
regulation of lymphocyte migration [GO:2000401];
regulation of organelle assembly [GO:1902115]
Gene Ontology
(Molecular Function)
Complete annatation
cell adhesion molecule binding [GO:0050839];
double-stranded RNA binding [GO:0003725];
protein kinase binding [GO:0019901];
receptor binding [GO:0005102];
structural constituent of cytoskeleton [GO:0005200]
Gene Ontology
(Cellular Component)
Complete annatation
apical part of cell [GO:0045177];
apical plasma membrane [GO:0016324];
basolateral plasma membrane [GO:0016323];
blood microparticle [GO:0072562];
cell periphery [GO:0071944];
cytoplasm [GO:0005737];
cytoskeleton [GO:0005856];
extracellular exosome [GO:0070062];
extracellular space [GO:0005615];
extrinsic component of membrane [GO:0019898];
filopodium [GO:0030175];
focal adhesion [GO:0005925];
microvillus [GO:0005902];
microvillus membrane [GO:0031528];
myelin sheath [GO:0043209];
nucleus [GO:0005634];
perinuclear region of cytoplasm [GO:0048471];
plasma membrane [GO:0005886];
pseudopodium [GO:0031143];
uropod [GO:0001931];
vesicle [GO:0031982]
Protein-protein interaction110584
Phylogenetic treeP26038
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
      unknown
Brass et al., Science, 2008
      unknown
Smith et al., J. Immunol, 2010
      unknown
Interferon-stimulated
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model


DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-0.4583358117725030.1614767361422310.257901385479335
AZA vs. DISU-0.0186943864547920.9410931925710910.996198528027442
AZA vs. IL70.1562233443275740.4147920953244510.999311006273513
AZA vs. SAHA-0.1211561041593360.6183724094532880.87646258614782
DISU vs. CD30.4271562791037060.2392832026046330.364522991011848
DISU vs. IL70.1652829134020440.5135398905175120.83380605308813
DISU vs. SAHA-0.09972390536084760.7320151878100630.921654210149161
DMSO vs. AZA0.03680360453236540.8252072894610661
DMSO vs. CD30.4858776724183040.1289761162129150.209988672943648
DMSO vs. DISU0.05424008197982360.8245676783861450.98057019242518
DMSO vs. IL70.1264213288306270.4800270893838180.880686160922201
DMSO vs. SAHA-0.1639025169244270.4860720308025020.806468496430312
HIV vs. Mock in Activation0.488364891872850.4331469171937240.999983755607037
HIV vs. Mock in Latency0.1431875892987040.3836057322026370.999834320637052
IL7 vs. CD30.6200356568834060.05429967950158190.117645403065595
SAHA vs. CD30.3143614836535620.3729015666411870.489514513003719
SAHA vs. IL7-0.2792959483351910.2511090713679450.494561400746154
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) FALSE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.353243 0.00976514
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
1.019 1.043 1.24 1.426 1.121
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
1E5W X-ray 2.7Å A=2-346.
1EF1 X-ray 1.9Å A/B=4-297# C/D=488-577.
1SGH X-ray 3.5Å A=1-297.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Vpu interacts with 22190034
Pr55(Gag) incorporates 8892894
Vpr downregulates 17349711
Pr55(Gag) co-localizes with 24760896
Envelope surface glycoprotein gp120 relocalizes 15818415
Envelope surface glycoprotein gp120 modulated by 19066282
Envelope surface glycoprotein gp120 binds 9213396
15818415
18295815
HIV-1 virus replication enhanced by expression of human gene 19460752
Envelope surface glycoprotein gp120 induces phosphorylation of 19066282

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04530 Tight junction - Homo sapiens (human)
hsa04670 Leukocyte transendothelial migration - Homo sapiens (human)
hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human)
hsa05162 Measles - Homo sapiens (human)
hsa05205 Proteoglycans in cancer - Homo sapiens (human)
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