Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0001800
UniProt IDO00566
Primary gene name(s)MPHOSPH10
Synonym gene name(s)MPP10
Protein nameU3 small nucleolar ribonucleoprotein protein MPP10
Protein functionComponent of the 60-80S U3 small nucleolar ribonucleoprotein, U3 snoRNP. Required for the early cleavages during pre-18S ribosomal RNA processing.
Subcellular locationNucleus, nucleolus {ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:12655004, ECO:0000269|PubMed:9450966}. Chromosome {ECO:0000269|PubMed:9450966}. Note=Fibrillar region of the nucleolus, PubMed:9450966. After dissolution of the nucleolus in early M phase becomes associated with chromosomes through metaphase and anaphase, PubMed:9450966. In telophase localized to small cellular prenucleolar bodies that not always contain fibrillarin, PubMed:9450966. The reassociation with nucleolus is preceeded by the arrival of fibrillarin, PubMed:9450966. {ECO:0000269|PubMed:9450966}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: O00566
Gene Ontology
(Biological Process)
Complete annatation
maturation of SSU-rRNA [GO:0030490];
negative regulation of phosphatase activity [GO:0010923];
RNA processing [GO:0006396];
RNA splicing [GO:0008380];
RNA splicing, via transesterification reactions [GO:0000375];
rRNA processing [GO:0006364]
Gene Ontology
(Molecular Function)
Complete annatation
poly(A RNA binding [GO:0044822]
Gene Ontology
(Cellular Component)
Complete annatation
chromosome [GO:0005694];
Mpp10 complex [GO:0034457];
nucleolus [GO:0005730];
nucleoplasm [GO:0005654];
small nucleolar ribonucleoprotein complex [GO:0005732];
small-subunit processome [GO:0032040]
Protein-protein interaction115494
Phylogenetic treeO00566
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD31.360494953993354.38732243169815e-050.000233001140558684
AZA vs. DISU-0.04952351279420390.8449862404722160.987834633347355
AZA vs. IL70.2308450336664770.2314689724927540.990920320206469
AZA vs. SAHA-0.3987987509770440.1035146830037760.408155985246904
DISU vs. CD3-1.422573808447130.0001165040639999890.000648995661764907
DISU vs. IL70.2716964755722790.2818862054640680.669501795490482
DISU vs. SAHA-0.3488048818944430.2322795116594250.609413602012501
DMSO vs. AZA-0.1049351207513910.5332612393998191
DMSO vs. CD3-1.475558926686126.05108158102663e-063.66249674641085e-05
DMSO vs. DISU-0.0568023793203560.8162433342678680.980295078677667
DMSO vs. IL70.3427945526338030.05764096561264410.467701055378083
DMSO vs. SAHA-0.3017801903551520.2022601233989670.54252760749845
HIV vs. Mock in Activation-0.160870530754780.7958035726631560.999983755607037
HIV vs. Mock in Latency0.01406898805572140.9324005997568410.999834320637052
IL7 vs. CD3-1.120786124667970.0005592712200884750.00258110688928156
SAHA vs. CD3-1.784926816101279.20460336617523e-077.51833998527159e-06
SAHA vs. IL7-0.6337727499336080.009706921987426620.0611970481131196
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change -1.063531591
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) FALSE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.24079 0.0884553
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
0.941 1.046 0.841 0.63 0.906
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa03008 Ribosome biogenesis in eukaryotes - Homo sapiens (human)