Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0001799
UniProt IDQ9HCE1
Primary gene name(s)MOV10
Synonym gene name(s)KIAA1631
Protein namePutative helicase MOV-10
Protein functionProbable RNA helicase. Required for miRNA-mediated gene silencing by the RNA-induced silencing complex, RISC. Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC. {ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:17507929, ECO:0000269|PubMed:22791714}.; FUNCTION:, Microbial infection Required for RNA-directed transcription and replication of the human hepatitis delta virus, HDV. Interacts with small capped HDV RNAs derived from genomic hairpin structures that mark the initiation sites of RNA-dependent HDV RNA transcription. {ECO:0000269|PubMed:18552826}.
Subcellular locationCytoplasm, P-body {ECO:0000269|PubMed:16289642}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q9HCE1
Gene Ontology
(Biological Process)
Complete annatation
gene silencing by miRNA [GO:0035195];
mRNA cleavage involved in gene silencing by miRNA [GO:0035279];
phosphatidylinositol-mediated signaling [GO:0048015];
regulation of transcription, DNA-templated [GO:0006355];
transcription, DNA-templated [GO:0006351];
Wnt signaling pathway, calcium modulating pathway [GO:0007223]
Gene Ontology
(Molecular Function)
Complete annatation
ATP binding [GO:0005524];
helicase activity [GO:0004386];
poly(A RNA binding [GO:0044822]
Gene Ontology
(Cellular Component)
Complete annatation
cytoplasmic mRNA processing body [GO:0000932];
cytosol [GO:0005829];
extracellular space [GO:0005615]
Protein-protein interaction110484
Phylogenetic treeQ9HCE1
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: HIV-1; HCV
      Viral life cycle: post-entry, HIV-1
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-0.1172213844025620.7218379735246980.803291077047541
AZA vs. DISU-0.08977981772392840.7243607131394110.974208899704183
AZA vs. IL7-0.01985424303886580.9187674317641020.999311006273513
AZA vs. SAHA0.1977260083636940.4210944016707050.77445379597836
DISU vs. CD30.01482091566178960.9674822972070720.979766754994921
DISU vs. IL70.06045877831524510.8114041557320280.959706420973601
DISU vs. SAHA0.2898474834222380.3224614920354830.705241205408034
DMSO vs. AZA0.07804284792401220.6467961125888771
DMSO vs. CD30.1811277955511260.5731374448625950.673323672320938
DMSO vs. DISU0.1654789598599060.5003120101451110.908069612536049
DMSO vs. IL7-0.09023056094096740.6202004097906610.917286151060713
DMSO vs. SAHA0.1151224542143870.6275745548239650.878362264431999
HIV vs. Mock in Activation0.4102581449563190.5114022751505150.999983755607037
HIV vs. Mock in Latency-0.05409992386036220.7450739776402840.999834320637052
IL7 vs. CD30.1027836155524360.7499478947559650.833687190622956
SAHA vs. CD30.2912302660400460.4132645561330290.528594199705037
SAHA vs. IL70.2150029716260450.3810003498909270.63181510167831
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) TRUE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.0225912 0.919188
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
1.033 1.031 0.881 0.792 1.064
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Pr55(Gag) incorporates 23926332
Pr55(Gag) inhibited by 20668078
Gag-Pol complexes with 23125841
nucleocapsid interacts with 20215113
Rev requires 26379090
HIV-1 virus replication enhanced by expression of human gene 26379090
Pr55(Gag) interacts with 20215113
Nef complexes with 23125841
Pr55(Gag) enhanced by 26379090
Pr55(Gag) binds 22105071
Rev interacts with 26379090
Envelope surface glycoprotein gp120 complexes with 23125841
Rev upregulated by 26379090
Pr55(Gag) complexes with 23125841

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
not found