Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0001794
UniProt IDQ9Y5R2
Primary gene name(s)MMP24
Synonym gene name(s)MT5MMP
Protein nameMatrix metalloproteinase-24
Protein functionMetalloprotease that mediates cleavage of N-cadherin, CDH2 and acts as a regulator of neuro-immune interactions and neural stem cell quiescence. Involved in cell-cell interactions between nociceptive neurites and mast cells, possibly by mediating cleavage of CDH2, thereby acting as a mediator of peripheral thermal nociception and inflammatory hyperalgesia. Key regulator of neural stem cells quiescence by mediating cleavage of CDH2, affecting CDH2-mediated anchorage of neural stem cells to ependymocytes in the adult subependymal zone, leading to modulate their quiescence. May play a role in axonal growth. Able to activate progelatinase A. May also be a proteoglycanase involved in degradation of proteoglycans, such as dermatan sulfate and chondroitin sulfate proteoglycans. Cleaves partially fibronectin, but not collagen type I, nor laminin, By similarity. {ECO:0000250}.
Subcellular locationMatrix metalloproteinase-24: Cell membrane {ECO:0000250};
Single-pass type I membrane protein {ECO:0000250}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250};
Single-pass type I membrane protein {ECO:0000250}. Note=Recycled back to the plasma membrane through the trans-Golgi network via interaction with APBA3. {ECO:0000250}.;
SUBCELLULAR LOCATION: Processed matrix metalloproteinase-24: Secreted, extracellular space, extracellular matrix {ECO:0000250}. Note=Also shed from cell surface as soluble proteinase, by a proteolytic cleavage. {ECO:0000250}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q9Y5R2
Gene Ontology
(Biological Process)
Complete annatation
cell-cell adhesion [GO:0098609];
cell-cell adhesion mediated by cadherin [GO:0044331];
detection of temperature stimulus involved in sensory perception of pain [GO:0050965];
glial cell differentiation [GO:0010001];
neuronal stem cell population maintenance [GO:0097150];
proteolysis [GO:0006508]
Gene Ontology
(Molecular Function)
Complete annatation
calcium ion binding [GO:0005509];
enzyme activator activity [GO:0008047];
metalloendopeptidase activity [GO:0004222];
zinc ion binding [GO:0008270]
Gene Ontology
(Cellular Component)
Complete annatation
extracellular exosome [GO:0070062];
integral component of plasma membrane [GO:0005887];
proteinaceous extracellular matrix [GO:0005578];
trans-Golgi network membrane [GO:0032588]
Protein-protein interactionunknown
Phylogenetic treeQ9Y5R2
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-1.425638807642612.99641204207779e-050.000166339254884759
AZA vs. DISU-0.008133161744268850.9750001397419630.997811953897277
AZA vs. IL7-0.8552977194973983.3155455848366e-050.00734929685297677
AZA vs. SAHA-0.7158710358597680.005505437680518920.066263387931975
DISU vs. CD31.40521234916410.0001825033945200840.000959224605647051
DISU vs. IL7-0.8576539230284470.001076654241091050.0286759058029108
DISU vs. SAHA-0.7065099367826540.02048226945014360.16505009064815
DMSO vs. AZA-0.05317841989916610.7661143553245431
DMSO vs. CD31.358011462990654.53849552159991e-050.000222204858735465
DMSO vs. DISU-0.04772927913022480.8488044783351030.982583769983649
DMSO vs. IL7-0.794414289345393.97788716955949e-050.00611904582460299
DMSO vs. SAHA-0.6676337643088730.007296128569857730.072914021248763
HIV vs. Mock in Activation0.214240540372480.738670020206720.999983755607037
HIV vs. Mock in Latency0.1127458441399690.5250621721787140.999834320637052
IL7 vs. CD30.5749441436424360.08458534285299630.166269545229944
SAHA vs. CD30.6831692637044840.06533087154151440.123685456549073
SAHA vs. IL70.1342636587747190.6026460028831080.798970624938181
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) TRUE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.108914 0.509342
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

Drugbank ID Drug Name Drug Status Pharmacological Action Drug Action
DB00786 Marimastat approved, investigational yes inhibitor

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
not found