Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0001792
UniProt IDP50281
Primary gene name(s)MMP14
Synonym gene name(s)unknown
Protein nameMatrix metalloproteinase-14
Protein functionSeems to specifically activate progelatinase A. May thus trigger invasion by tumor cells by activating progelatinase A on the tumor cell surface. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive regulator of cell growth and migration via activation of MMP15. Involved in the formation of the fibrovascular tissues in association with pro-MMP2. {ECO:0000269|PubMed:12714657, ECO:0000269|PubMed:20837484, ECO:0000269|PubMed:22065321}.
Subcellular locationMembrane {ECO:0000305};
Single-pass type I membrane protein {ECO:0000305}. Melanosome. Cytoplasm. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Forms a complex with BST2 and localizes to the cytoplasm.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P50281
Gene Ontology
(Biological Process)
Complete annatation
angiogenesis [GO:0001525];
astrocyte cell migration [GO:0043615];
branching morphogenesis of an epithelial tube [GO:0048754];
cell motility [GO:0048870];
chondrocyte proliferation [GO:0035988];
collagen catabolic process [GO:0030574];
craniofacial suture morphogenesis [GO:0097094];
embryonic cranial skeleton morphogenesis [GO:0048701];
endochondral ossification [GO:0001958];
endodermal cell differentiation [GO:0035987];
endothelial cell proliferation [GO:0001935];
extracellular matrix disassembly [GO:0022617];
lung development [GO:0030324];
male gonad development [GO:0008584];
negative regulation of focal adhesion assembly [GO:0051895];
negative regulation of Notch signaling pathway [GO:0045746];
ovarian follicle development [GO:0001541];
positive regulation of B cell differentiation [GO:0045579];
positive regulation of cell growth [GO:0030307];
positive regulation of cell migration [GO:0030335];
positive regulation of myotube differentiation [GO:0010831];
protein processing [GO:0016485];
proteolysis [GO:0006508];
response to estrogen [GO:0043627];
response to hormone [GO:0009725];
response to hypoxia [GO:0001666];
response to mechanical stimulus [GO:0009612];
response to organic cyclic compound [GO:0014070];
response to oxidative stress [GO:0006979];
tissue remodeling [GO:0048771];
zymogen activation [GO:0031638]
Gene Ontology
(Molecular Function)
Complete annatation
calcium ion binding [GO:0005509];
metalloendopeptidase activity [GO:0004222];
peptidase activator activity [GO:0016504];
serine-type endopeptidase activity [GO:0004252];
zinc ion binding [GO:0008270]
Gene Ontology
(Cellular Component)
Complete annatation
cytoplasmic vesicle [GO:0031410];
extracellular matrix [GO:0031012];
focal adhesion [GO:0005925];
Golgi lumen [GO:0005796];
integral component of plasma membrane [GO:0005887];
macropinosome [GO:0044354];
melanosome [GO:0042470];
plasma membrane [GO:0005886]
Protein-protein interaction110466
Phylogenetic treeP50281
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-0.4594472192607570.4594860143754550.579577639021412
AZA vs. DISU-0.05234049791650580.9344029813820850.995042856396371
AZA vs. IL7-0.2253741213099370.7003233929209010.999311006273513
AZA vs. SAHA0.2493200514653180.5536812221476930.848017754791133
DISU vs. CD30.3926577495079490.5868879173205260.700566080589928
DISU vs. IL7-0.1821141654456860.784038133387510.950465331549835
DISU vs. SAHA0.3062313075213360.5697894158762880.860487595163211
DMSO vs. AZA0.2354451220562490.6698043105763361
DMSO vs. CD30.6803927200810930.2724002751009730.380854769781546
DMSO vs. DISU0.2858616865357950.652267579677370.949713766615536
DMSO vs. IL7-0.4531169620072510.4383578647425340.861570379529818
DMSO vs. SAHA0.01053984824060940.979841477234990.995227854387959
HIV vs. Mock in Activation-0.526126508622830.655356539263790.999983755607037
HIV vs. Mock in Latency0.1641731098350930.7932904797004410.999834320637052
IL7 vs. CD30.2389769573796210.7184416990631440.810275376592771
SAHA vs. CD30.6868326502555640.1485259662475530.2392609632657
SAHA vs. IL70.47232385778050.3201435351824710.569622715927828
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) TRUE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 1.67689 0.000305467
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

Drugbank ID Drug Name Drug Status Pharmacological Action Drug Action
DB00786 Marimastat approved, investigational yes inhibitor

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
1BQQ X-ray 2.7Å M=114-287.
1BUV X-ray 2.7Å M=114-287.
2MQS NMR - A=316-511.
3C7X X-ray 1.7Å A=316-511.
3MA2 X-ray 2.0Å A/D=112-292.
3X23 X-ray 2.4Å B=563-582.
4P3C X-ray 1.9Å M=215-227.
4P3D X-ray 1.9Å C/M=215-227.
4QXU X-ray 2.3Å K=218-228.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Envelope transmembrane glycoprotein gp41 upregulates 23383108

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04668 TNF signaling pathway - Homo sapiens (human)
hsa04912 GnRH signaling pathway - Homo sapiens (human)