Database ID | HIV0001725 |
UniProt ID | Q07820 |
Primary gene name(s) | MCL1 |
Synonym gene name(s) | BCL2L3 |
Protein name | Induced myeloid leukemia cell differentiation protein Mcl-1 |
Protein function | Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis. {ECO:0000269|PubMed:10766760, ECO:0000269|PubMed:16543145}. |
Subcellular location | Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Cytoplasm. Mitochondrion. Nucleus, nucleoplasm. Note=Cytoplasmic, associated with mitochondria. |
ECO code | Click here for more information. |
Amino acid sequence FASTA format: Q07820 |
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Gene Ontology (Biological Process) Complete annatation | apoptotic mitochondrial changes [GO:0008637]; cell fate determination [GO:0001709]; cellular homeostasis [GO:0019725]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; multicellular organism development [GO:0007275]; negative regulation of anoikis [GO:2000811]; negative regulation of apoptotic process [GO:0043066]; negative regulation of autophagy [GO:0010507]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903378]; regulation of response to DNA damage stimulus [GO:2001020]; response to cytokine [GO:0034097] |
Gene Ontology (Molecular Function) Complete annatation | BH3 domain binding [GO:0051434]; protein channel activity [GO:0015266]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803] |
Gene Ontology (Cellular Component) Complete annatation | Bcl-2 family protein complex [GO:0097136]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; integral component of membrane [GO:0016021]; membrane [GO:0016020]; mitochondrial matrix [GO:0005759]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634] |
Protein-protein interaction | 110338 |
Phylogenetic tree | Q07820 |
HIV replication factor status |
Zhou et al., Cell. Host. Microbe., 2008 unknown Brass et al., Science, 2008 unknown Smith et al., J. Immunol, 2010 unknown |
Interferon-stimulated gene status |
Lu et al., J. Virol., 2011 Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown; Schoggins JW and Rice CM, Curr. Opin. Virol., 2011 Targeted viruses: unknown Viral life cycle: unknown Mechanism related to antiviral activity: unknown |
Anti-viral restriction factor |
Liu et al., Retrovirology, 2011 unknown (Triplicates) |
Up-regulated;
Down-regulated
For brief introduction to each study, please go to the help page.
(1). Mohammadi et al., PLoS Pathog., 2014 Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model DMSO: Dimethyl suloxyde (negative control) - 0.0033% final SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies IL7: Interleukin-7 based stimulation DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM |
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Experimental Condition | Log2 Fold Change | P value | Adjusted P value |
AZA vs. CD3 | -0.446739547612762 | 0.172314531435084 | 0.271722600731281 |
AZA vs. DISU | 0.0512613715453958 | 0.838936028154031 | 0.986623420073108 |
AZA vs. IL7 | -0.173354098852145 | 0.365406711141766 | 0.999311006273513 |
AZA vs. SAHA | -0.165047149879764 | 0.497475202043959 | 0.819791303145915 |
DISU vs. CD3 | 0.48644171097034 | 0.179681145133239 | 0.293733172295678 |
DISU vs. IL7 | -0.234273387996899 | 0.351280531897186 | 0.732180363653542 |
DISU vs. SAHA | -0.214990773712216 | 0.45979187049258 | 0.798937533514497 |
DMSO vs. AZA | -0.0734049238305177 | 0.659535611188947 | 1 |
DMSO vs. CD3 | 0.364866748760349 | 0.253422401319005 | 0.359729433324302 |
DMSO vs. DISU | -0.125789450615939 | 0.605142848632478 | 0.939289650701039 |
DMSO vs. IL7 | -0.0931538081265492 | 0.602888234057787 | 0.912604767320708 |
DMSO vs. SAHA | -0.0989291894748235 | 0.673875601780865 | 0.897786781843686 |
HIV vs. Mock in Activation | -0.0298965909225966 | 0.961655469934068 | 0.999983755607037 |
HIV vs. Mock in Latency | 0.00704755365254877 | 0.965772463099617 | 0.999834320637052 |
IL7 vs. CD3 | 0.280429596652319 | 0.382237394997765 | 0.51895732794103 |
SAHA vs. CD3 | 0.257656301205813 | 0.465081550338035 | 0.576954171806685 |
SAHA vs. IL7 | 0.00521522827230828 | 0.982875077640711 | 0.993710617125574 |
(2). Iglesias-Ussel et al., J. Virol., 2013 Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model |
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Log2 Fold Change | P Value | ||
unknown | unknown |
(1). Imbeault et al., PloS Pathog., 2012 Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells |
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Experiment type | Log2 Fold Change | P Value | Adjusted P Value | ||
Infected vs. Mock | unknown | unknown | unknown | ||
Infected vs. Bystander | unknown | unknown | unknown | ||
(2). Lefebvre et al., J. Virol., 2011 Transcriptome analysis of T-cell line (Sup T1) |
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Log2 Fold Change | unknown | ||||
(3). Li et al., J. Immunol., 2013 Lymphatic tissue |
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Acute Fold Change | Acute P Value | Asymt Fold Change | Asypt P Value | AIDS Fold Change | AIDS P Value |
unknown | unknown | unknown | unknown | unknown | unknown |
(4). Chang et al., MBio., 2011 Transcriptome analysis of T-cell line (Sup T1) Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation |
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Up-regulated (True) | FALSE | ||||
(5). Sherrill-Mix et al., BMC Retrovirol., 2015 Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based |
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Test Status | Log2 Fold Change | P Value | |||
OK | -0.214326 | 0.240819 | |||
(6). Rotger et al., PLoS Pathog., 2010 Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient (Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach) |
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Log2 Fold Change | P Value | ||||
unknown | unknown |
(1). Greenwood et al., Elife, 2016 Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset |
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6 h | 24 h | 48 h | 72 h | RTi | ||
1.097 | 1.256 | 0.89 | 0.796 | 0.926 | ||
(2). Navare et al., Virology, 2012 SUP-T1 cell line |
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FC-4hpi | P-value | FC-8hpi | P-value | FC-20hpi | P-value | Category |
unknown | unknown | unknown | unknown | unknown | unknown | unknown |
(3). Hyrcza et al., J. Virolo., 2007 Primary human CD4+ and CD8+ T Cells |
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Affymetrix Prob ID | Fold Change | In CD8? | Category | |||
unknown | unknown | unknown | unknown |
PDB Accession | Method | Resolution | Chain | Structure Preview |
---|---|---|---|---|
2KBW | NMR | - | A=163-326. | ![]() |
2MHS | NMR | - | A=171-327. | ![]() |
2NL9 | X-ray | 1.5Å | A=209-327. | ![]() |
2NLA | X-ray | 2.8Å | A=209-327. | ![]() |
2PQK | X-ray | 2.0Å | A=172-327. | ![]() |
3D7V | X-ray | 2.0Å | A=209-327. | ![]() |
3IO9 | X-ray | 2.4Å | A=209-327. | ![]() |
3KJ0 | X-ray | 1.7Å | A=172-327. | ![]() |
3KJ1 | X-ray | 1.9Å | A=172-327. | ![]() |
3KJ2 | X-ray | 2.3Å | A=172-327. | ![]() |
3KZ0 | X-ray | 2.3Å | A/B=172-327. | ![]() |
3MK8 | X-ray | 2.3Å | A=172-327# B=208-228. | ![]() |
3PK1 | X-ray | 2.4Å | A/C=174-326. | ![]() |
3TWU | X-ray | 1.8Å | B=73-88. | ![]() |
3WIX | X-ray | 1.9Å | A/B/C/D=172-327. | ![]() |
3WIY | X-ray | 2.1Å | A/B/C/D/E/F=172-327. | ![]() |
4BPI | X-ray | 1.9Å | A=209-327. | ![]() |
4BPJ | X-ray | 1.6Å | A=209-327. | ![]() |
4HW2 | X-ray | 2.8Å | A/B/C/D/E/F=172-323. | ![]() |
4HW3 | X-ray | 2.4Å | A/B/C/D/E/F/G/H/I/J/K/L=172-323. | ![]() |
4HW4 | X-ray | 1.5Å | A/B=172-327. | ![]() |
4OQ5 | X-ray | 2.8Å | A/B/C/D/E/F=174-326. | ![]() |
4OQ6 | X-ray | 1.8Å | A/B=174-326. | ![]() |
4WGI | X-ray | 1.8Å | A=173-321. | ![]() |
4WMR | X-ray | 1.7Å | A=173-321. | ![]() |
4WMS | X-ray | 1.9Å | A=174-321. | ![]() |
4WMT | X-ray | 2.3Å | A=174-321. | ![]() |
4WMU | X-ray | 1.5Å | A=174-321. | ![]() |
4WMV | X-ray | 2.4Å | A=174-321. | ![]() |
4WMW | X-ray | 1.9Å | A=174-321. | ![]() |
4WMX | X-ray | 2.0Å | A=174-321. | ![]() |
4ZBF | X-ray | 2.2Å | A/B/C/D/E/F/G/H/I/J/K/L=172-327. | ![]() |
4ZBI | X-ray | 2.5Å | A/B/C/D/E/F/G/H/I/J/K/L=172-327. | ![]() |
5C3F | X-ray | 1.4Å | A=173-327. | ![]() |
5C6H | X-ray | 2.0Å | A/C/E/G/I/K/M/O/Q/S/U/W=171-327. | ![]() |
5FC4 | X-ray | 1.5Å | A=172-320. | ![]() |
5FDO | X-ray | 2.8Å | A/B/C/D=172-320. | ![]() |
5FDR | X-ray | 2.6Å | A/B/C/D=172-327. | ![]() |