Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0001708
UniProt IDP49006
Primary gene name(s)MARCKSL1
Synonym gene name(s)MLP, MRP
Protein nameMARCKS-related protein
Protein functionControls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation. When unphosphorylated, induces cell migration. When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration. May also affect cancer cell migration. May be involved in coupling the protein kinase C and calmodulin signal transduction systems, By similarity. {ECO:0000250}.
Subcellular locationCytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Membrane {ECO:0000305};
Lipid-anchor {ECO:0000305}. Note=Associates with the membrane via the insertion of the N-terminal N-myristoyl chain and the partial insertion of the effector domain. Association of the effector domain with membranes may be regulated by Ca(2+/calmodulin, By similarity. In prostate cancers, detected in the cytoplasm and associated with apical or basal membranes, By similarity. {ECO:0000250}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P49006
Gene Ontology
(Biological Process)
Complete annatation
positive regulation of cell proliferation [GO:0008284]
Gene Ontology
(Molecular Function)
Complete annatation
unknown
Gene Ontology
(Cellular Component)
Complete annatation
cytoplasm [GO:0005737];
extracellular exosome [GO:0070062];
plasma membrane [GO:0005886]
Protein-protein interaction122395
Phylogenetic treeP49006
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
      unknown
Brass et al., Science, 2008
      unknown
Smith et al., J. Immunol, 2010
      unknown
Interferon-stimulated
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model


DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-0.1887092465535690.5707657308623230.679493722372975
AZA vs. DISU-0.460394528184240.07658888537969260.590222266291186
AZA vs. IL7-0.7070600529685340.0004831743850485240.0467894895338611
AZA vs. SAHA1.032334325905870.02538019076758860.179615490906399
DISU vs. CD3-0.2839942053245520.4383772207047320.569712753246239
DISU vs. IL7-0.2555035334091270.3257206520372720.706204347686162
DISU vs. SAHA1.493110728622230.0009930366097896660.0206817675544175
DMSO vs. AZA0.02282935735062640.9180866096700821
DMSO vs. CD30.1922014011894690.5549535238760690.658400916458732
DMSO vs. DISU0.4790034290451980.05639479894800940.462030784075704
DMSO vs. IL7-0.7210728997242730.0003472958028891690.0278483203646501
DMSO vs. SAHA1.004019026697670.03587622843667170.206923321381201
HIV vs. Mock in Activation-0.2620675609184760.6805596450387890.999983755607037
HIV vs. Mock in Latency-0.6320391966361250.000300496903667180.0254425287810848
IL7 vs. CD3-0.509056406386970.1212341438719630.219606401996089
SAHA vs. CD31.195207458975290.01508595992315490.0362997630595472
SAHA vs. IL71.734595486181270.0001883102398234640.00320382455428769
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) FALSE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.0353315 0.851292
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
0.955 1.159 1.066 1.22 1.622
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04666 Fc gamma R-mediated phagocytosis - Homo sapiens (human)
hsa05140 Leishmaniasis - Homo sapiens (human)
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