Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0001683
UniProt IDP21145
Primary gene name(s)MAL
Synonym gene name(s)unknown
Protein nameMyelin and lymphocyte protein
Protein functionCould be an important component in vesicular trafficking cycling between the Golgi complex and the apical plasma membrane. Could be involved in myelin biogenesis and/or myelin function.
Subcellular locationMembrane;
Multi-pass membrane protein.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P21145
Gene Ontology
(Biological Process)
Complete annatation
apical protein localization [GO:0045176];
apoptotic process [GO:0006915];
cell differentiation [GO:0030154];
central nervous system development [GO:0007417];
membrane raft polarization [GO:0001766];
myelination [GO:0042552];
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902043]
Gene Ontology
(Molecular Function)
Complete annatation
channel activity [GO:0015267];
lipid binding [GO:0008289];
peptidase activator activity involved in apoptotic process [GO:0016505];
structural constituent of myelin sheath [GO:0019911]
Gene Ontology
(Cellular Component)
Complete annatation
apical plasma membrane [GO:0016324];
endoplasmic reticulum [GO:0005783];
endosome [GO:0005768];
extrinsic component of membrane [GO:0019898];
integral component of plasma membrane [GO:0005887];
membrane raft [GO:0045121]
Protein-protein interaction110292
Phylogenetic treeP21145
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-1.843635848621347.13733425694585e-087.12882053815029e-07
AZA vs. DISU-0.2375328074585190.3475993894611390.885086688638042
AZA vs. IL70.2030631662946270.2908637576989970.999311006273513
AZA vs. SAHA-0.6091569387100510.01350125601466010.118807900271446
DISU vs. CD31.594365797461922.10630170117687e-050.000143472172813105
DISU vs. IL70.4312202310402450.0871966448636580.390287832933386
DISU vs. SAHA-0.3696406259486830.2074187251007110.581474629090925
DMSO vs. AZA-0.03935525621358690.8141590759255131
DMSO vs. CD31.789903675261587.65178937989219e-086.87793597900214e-07
DMSO vs. DISU0.1955935870950530.4224950683087480.877843744576429
DMSO vs. IL70.250064544739990.164226161227150.67147816640446
DMSO vs. SAHA-0.5745088125595640.01571425748123920.120769798317061
HIV vs. Mock in Activation0.3135125041437150.61560820622270.999983755607037
HIV vs. Mock in Latency-0.1497047588630120.365688036808370.999834320637052
IL7 vs. CD32.053218615315049.947445089864e-101.78285184113579e-08
SAHA vs. CD31.210753348308610.000738244278769340.00275926123042013
SAHA vs. IL7-0.8151959108111650.0009077256540358510.0108166454616098
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock -0.944 1.43E-14 3.97E-11
Infected vs. Bystander -1.019 2.66E-15 6.17E-12
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change -1.210071216
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
-1 0.497629114 -1.4 0.00613411 -2.1 7.92E-05
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) FALSE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 1.31684 0.000305467
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Nef interacts with 26109641

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
not found