Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0001664
UniProt IDQ8N2S1
Primary gene name(s)LTBP4
Synonym gene name(s)unknown
Protein nameLatent-transforming growth factor beta-binding protein 4
Protein functionMay be involved in the assembly, secretion and targeting of TGFB1 to sites at which it is stored and/or activated. May play critical roles in controlling and directing the activity of TGFB1. May have a structural role in the extra cellular matrix, ECM, By similarity. {ECO:0000250}.
Subcellular locationSecreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:16157329, ECO:0000269|PubMed:9660815}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q8N2S1
Gene Ontology
(Biological Process)
Complete annatation
growth hormone secretion [GO:0030252];
multicellular organism development [GO:0007275];
protein folding [GO:0006457];
regulation of cell differentiation [GO:0045595];
regulation of cell growth [GO:0001558];
regulation of proteolysis [GO:0030162];
regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]
Gene Ontology
(Molecular Function)
Complete annatation
calcium ion binding [GO:0005509];
glycosaminoglycan binding [GO:0005539];
integrin binding [GO:0005178];
transforming growth factor beta-activated receptor activity [GO:0005024];
transforming growth factor beta binding [GO:0050431]
Gene Ontology
(Cellular Component)
Complete annatation
extracellular exosome [GO:0070062];
extracellular matrix [GO:0031012];
extracellular region [GO:0005576];
extracellular space [GO:0005615];
proteinaceous extracellular matrix [GO:0005578]
Protein-protein interaction114009
Phylogenetic treeQ8N2S1
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-0.6565177139999020.2972182537499260.415322966856934
AZA vs. DISU-0.2025566680662380.4253887066984140.913479265604449
AZA vs. IL7-0.3895789901613520.0980839704933190.833343590495724
AZA vs. SAHA0.2311181555533130.3438058064849540.715818884938426
DISU vs. CD30.4415455106189860.4820755441877770.609580299730438
DISU vs. IL7-0.196783202085070.4616029328429890.802603102529058
DISU vs. SAHA0.4361069668048380.1368099310906880.47488137030304
DMSO vs. AZA0.1026247789580350.5411135943459521
DMSO vs. CD30.7454475539673390.2348701231391610.339003917235816
DMSO vs. DISU0.3027492284854230.2170149870081580.729172299736022
DMSO vs. IL7-0.4845027985049470.03533971142066830.384932189065444
DMSO vs. SAHA0.1237396250949140.599713791102410.864246179547181
HIV vs. Mock in Activation0.2089763843150060.870626323608160.999983755607037
HIV vs. Mock in Latency-0.05803829246522310.7260782640125640.999834320637052
IL7 vs. CD30.2720763011542810.6842650290080040.784985674879187
SAHA vs. CD30.8646774777066210.176295308507640.273878869279679
SAHA vs. IL70.6171004796161640.0203789545481440.101652005578664
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) TRUE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.543552 0.000305467
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
not found