Database ID | HIV0001649 |
UniProt ID | P42704 |
Primary gene name(s) | LRPPRC |
Synonym gene name(s) | LRP130 |
Protein name | Leucine-rich PPR motif-containing protein, mitochondrial |
Protein function | May play a role in RNA metabolism in both nuclei and mitochondria. In the nucleus binds to HNRPA1-associated poly(A mRNAs and is part of nmRNP complexes at late stages of mRNA maturation which are possibly associated with nuclear mRNA export. May bind mature mRNA in the nucleus outer membrane. In mitochondria binds to poly(A mRNA. Plays a role in translation or stability of mitochondrially encoded cytochrome c oxidase, COX subunits. May be involved in transcription regulation. Cooperates with PPARGC1A to regulate certain mitochondrially encoded genes and gluconeogenic genes and may regulate docking of PPARGC1A to transcription factors. Seems to be involved in the transcription regulation of the multidrug-related genes MDR1 and MVP. Part of a nuclear factor that binds to the invMED1 element of MDR1 and MVP gene promoters. Binds single-stranded DNA, By similarity. {ECO:0000250, ECO:0000269|PubMed:11585913, ECO:0000269|PubMed:12832482, ECO:0000269|PubMed:15081402, ECO:0000269|PubMed:15139850, ECO:0000269|PubMed:15272088, ECO:0000269|PubMed:17050673}. |
Subcellular location | Mitochondrion. Nucleus, nucleoplasm. Nucleus inner membrane. Nucleus outer membrane. Note=Seems to be predominantly mitochondrial. |
ECO code | Click here for more information. |
Amino acid sequence FASTA format: P42704 |
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Gene Ontology (Biological Process) Complete annatation | mitochondrion transport along microtubule [GO:0047497]; mRNA transport [GO:0051028]; negative regulation of mitochondrial RNA catabolic process [GO:0000961]; regulation of mitochondrial translation [GO:0070129]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351] |
Gene Ontology (Molecular Function) Complete annatation | beta-tubulin binding [GO:0048487]; microtubule binding [GO:0008017]; poly(A RNA binding [GO:0044822]; RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697]; ubiquitin protein ligase binding [GO:0031625] |
Gene Ontology (Cellular Component) Complete annatation | condensed nuclear chromosome [GO:0000794]; cytoskeleton [GO:0005856]; intracellular ribonucleoprotein complex [GO:0030529]; membrane [GO:0016020]; microtubule [GO:0005874]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; nuclear inner membrane [GO:0005637]; nuclear outer membrane [GO:0005640]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471] |
Protein-protein interaction | 115432 |
Phylogenetic tree | P42704 |
HIV replication factor status |
Zhou et al., Cell. Host. Microbe., 2008 unknown Brass et al., Science, 2008 unknown Smith et al., J. Immunol, 2010 unknown |
Interferon-stimulated gene status |
Lu et al., J. Virol., 2011 Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown; Schoggins JW and Rice CM, Curr. Opin. Virol., 2011 Targeted viruses: unknown Viral life cycle: unknown Mechanism related to antiviral activity: unknown |
Anti-viral restriction factor |
Liu et al., Retrovirology, 2011 unknown (Triplicates) |
Up-regulated;
Down-regulated
For brief introduction to each study, please go to the help page.
(1). Mohammadi et al., PLoS Pathog., 2014 Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model DMSO: Dimethyl suloxyde (negative control) - 0.0033% final SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies IL7: Interleukin-7 based stimulation DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM |
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Experimental Condition | Log2 Fold Change | P value | Adjusted P value |
AZA vs. CD3 | 1.43921944464688 | 1.58075213547715e-05 | 9.31395472475042e-05 |
AZA vs. DISU | -0.147296809468649 | 0.560345234100304 | 0.950449427121412 |
AZA vs. IL7 | 0.313991110103963 | 0.118654161386133 | 0.879721679573626 |
AZA vs. SAHA | -0.02176673310681 | 0.928825643048868 | 0.983679933307882 |
DISU vs. CD3 | -1.59902397565371 | 1.6914068724061e-05 | 0.000118422049208776 |
DISU vs. IL7 | 0.452744627155838 | 0.0724299207039757 | 0.357864595233248 |
DISU vs. SAHA | 0.125731155175132 | 0.667076404611462 | 0.898758134623578 |
DMSO vs. AZA | -0.107789209732178 | 0.518931681245196 | 1 |
DMSO vs. CD3 | -1.55989452025875 | 1.78916129511819e-06 | 1.218522373913e-05 |
DMSO vs. DISU | 0.0372116805197732 | 0.878794285728994 | 0.987443803738299 |
DMSO vs. IL7 | 0.429245194694261 | 0.0169593373402442 | 0.271466805222618 |
DMSO vs. SAHA | 0.0787169511400343 | 0.738175578141316 | 0.924026643277682 |
HIV vs. Mock in Activation | -0.1193650512167 | 0.847732479582133 | 0.999983755607037 |
HIV vs. Mock in Latency | -0.024014813734338 | 0.884080363312881 | 0.999834320637052 |
IL7 vs. CD3 | -1.1158686694459 | 0.000595095622275554 | 0.00272392235486166 |
SAHA vs. CD3 | -1.48710751384943 | 3.63424751697039e-05 | 0.000196512773881391 |
SAHA vs. IL7 | -0.34014950511103 | 0.163201289331853 | 0.384462178123031 |
(2). Iglesias-Ussel et al., J. Virol., 2013 Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model |
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Log2 Fold Change | P Value | ||
unknown | unknown |
(1). Imbeault et al., PloS Pathog., 2012 Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells |
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Experiment type | Log2 Fold Change | P Value | Adjusted P Value | ||
Infected vs. Mock | unknown | unknown | unknown | ||
Infected vs. Bystander | unknown | unknown | unknown | ||
(2). Lefebvre et al., J. Virol., 2011 Transcriptome analysis of T-cell line (Sup T1) |
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Log2 Fold Change | unknown | ||||
(3). Li et al., J. Immunol., 2013 Lymphatic tissue |
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Acute Fold Change | Acute P Value | Asymt Fold Change | Asypt P Value | AIDS Fold Change | AIDS P Value |
unknown | unknown | unknown | unknown | unknown | unknown |
(4). Chang et al., MBio., 2011 Transcriptome analysis of T-cell line (Sup T1) Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation |
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Up-regulated (True) | FALSE | ||||
(5). Sherrill-Mix et al., BMC Retrovirol., 2015 Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based |
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Test Status | Log2 Fold Change | P Value | |||
OK | -0.0446533 | 0.807492 | |||
(6). Rotger et al., PLoS Pathog., 2010 Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient (Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach) |
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Log2 Fold Change | P Value | ||||
unknown | unknown |
(1). Greenwood et al., Elife, 2016 Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset |
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6 h | 24 h | 48 h | 72 h | RTi | ||
0.994 | 1.011 | 0.913 | 0.777 | 0.837 | ||
(2). Navare et al., Virology, 2012 SUP-T1 cell line |
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FC-4hpi | P-value | FC-8hpi | P-value | FC-20hpi | P-value | Category |
unknown | unknown | unknown | unknown | unknown | unknown | unknown |
(3). Hyrcza et al., J. Virolo., 2007 Primary human CD4+ and CD8+ T Cells |
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Affymetrix Prob ID | Fold Change | In CD8? | Category | |||
unknown | unknown | unknown | unknown |
HIV Partner | Interaction Type | PubMed |
---|---|---|
Vpu | interacts with |
22190034 |
Envelope surface glycoprotein gp120 | complexes with |
23125841 |
Gag-Pol | complexes with |
23125841 |
matrix | associates with |
22808186 |
integrase | associates with |
22808186 |
Pr55(Gag) | complexes with |
23125841 |
HIV-1 virus replication | enhanced by expression of human gene |
22808186 |
Nef | complexes with |
23125841 |
Pathway Accession Number | Description | not found |
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