Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0001649
UniProt IDP42704
Primary gene name(s)LRPPRC
Synonym gene name(s)LRP130
Protein nameLeucine-rich PPR motif-containing protein, mitochondrial
Protein functionMay play a role in RNA metabolism in both nuclei and mitochondria. In the nucleus binds to HNRPA1-associated poly(A mRNAs and is part of nmRNP complexes at late stages of mRNA maturation which are possibly associated with nuclear mRNA export. May bind mature mRNA in the nucleus outer membrane. In mitochondria binds to poly(A mRNA. Plays a role in translation or stability of mitochondrially encoded cytochrome c oxidase, COX subunits. May be involved in transcription regulation. Cooperates with PPARGC1A to regulate certain mitochondrially encoded genes and gluconeogenic genes and may regulate docking of PPARGC1A to transcription factors. Seems to be involved in the transcription regulation of the multidrug-related genes MDR1 and MVP. Part of a nuclear factor that binds to the invMED1 element of MDR1 and MVP gene promoters. Binds single-stranded DNA, By similarity. {ECO:0000250, ECO:0000269|PubMed:11585913, ECO:0000269|PubMed:12832482, ECO:0000269|PubMed:15081402, ECO:0000269|PubMed:15139850, ECO:0000269|PubMed:15272088, ECO:0000269|PubMed:17050673}.
Subcellular locationMitochondrion. Nucleus, nucleoplasm. Nucleus inner membrane. Nucleus outer membrane. Note=Seems to be predominantly mitochondrial.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P42704
Gene Ontology
(Biological Process)
Complete annatation		mitochondrion transport along microtubule [GO:0047497];
mRNA transport [GO:0051028];
negative regulation of mitochondrial RNA catabolic process [GO:0000961];
regulation of mitochondrial translation [GO:0070129];
regulation of transcription, DNA-templated [GO:0006355];
transcription, DNA-templated [GO:0006351]
Gene Ontology
(Molecular Function)
Complete annatation		beta-tubulin binding [GO:0048487];
microtubule binding [GO:0008017];
poly(A RNA binding [GO:0044822];
RNA binding [GO:0003723];
single-stranded DNA binding [GO:0003697];
ubiquitin protein ligase binding [GO:0031625]
Gene Ontology
(Cellular Component)
Complete annatation		condensed nuclear chromosome [GO:0000794];
cytoskeleton [GO:0005856];
intracellular ribonucleoprotein complex [GO:0030529];
membrane [GO:0016020];
microtubule [GO:0005874];
mitochondrial nucleoid [GO:0042645];
mitochondrion [GO:0005739];
nuclear inner membrane [GO:0005637];
nuclear outer membrane [GO:0005640];
nucleoplasm [GO:0005654];
nucleus [GO:0005634];
perinuclear region of cytoplasm [GO:0048471]
Protein-protein interaction115432
Phylogenetic treeP42704
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
      unknown
Brass et al., Science, 2008
      unknown
Smith et al., J. Immunol, 2010
      unknown
Interferon-stimulated
gene status		 Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD31.439219444646881.58075213547715e-059.31395472475042e-05
AZA vs. DISU-0.1472968094686490.5603452341003040.950449427121412
AZA vs. IL70.3139911101039630.1186541613861330.879721679573626
AZA vs. SAHA-0.021766733106810.9288256430488680.983679933307882
DISU vs. CD3-1.599023975653711.6914068724061e-050.000118422049208776
DISU vs. IL70.4527446271558380.07242992070397570.357864595233248
DISU vs. SAHA0.1257311551751320.6670764046114620.898758134623578
DMSO vs. AZA-0.1077892097321780.5189316812451961
DMSO vs. CD3-1.559894520258751.78916129511819e-061.218522373913e-05
DMSO vs. DISU0.03721168051977320.8787942857289940.987443803738299
DMSO vs. IL70.4292451946942610.01695933734024420.271466805222618
DMSO vs. SAHA0.07871695114003430.7381755781413160.924026643277682
HIV vs. Mock in Activation-0.11936505121670.8477324795821330.999983755607037
HIV vs. Mock in Latency-0.0240148137343380.8840803633128810.999834320637052
IL7 vs. CD3-1.11586866944590.0005950956222755540.00272392235486166
SAHA vs. CD3-1.487107513849433.63424751697039e-050.000196512773881391
SAHA vs. IL7-0.340149505111030.1632012893318530.384462178123031
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)
Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) FALSE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.0446533 0.807492
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
0.994 1.011 0.913 0.777 0.837
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Vpu interacts with 22190034
Envelope surface glycoprotein gp120 complexes with 23125841
Gag-Pol complexes with 23125841
matrix associates with 22808186
integrase associates with 22808186
Pr55(Gag) complexes with 23125841
HIV-1 virus replication enhanced by expression of human gene 22808186
Nef complexes with 23125841

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
not found

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Contacts

Dr. Chen Li
Address: Department of Biochemistry and Molecular Biology, Monash University, Melbourne, Australia, VIC 3800
Email: Chen Li at Monash

© 2017 HIVed Database, Purcell Lab, Department of Biochemistry and Molecular Biology, Monash University. All rights reserved.
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