Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0001639
UniProt IDQ9HBW0
Primary gene name(s)LPAR2
Synonym gene name(s)EDG4, LPA2
Protein nameLysophosphatidic acid receptor 2
Protein functionReceptor for lysophosphatidic acid, LPA, a mediator of diverse cellular activities. Seems to be coupled to the G(i/G(o, G(12/G(13, and G(q families of heteromeric G proteins. Plays a key role in phospholipase C-beta, PLC-beta signaling pathway. Stimulates phospholipase C, PLC activity in a manner that is independent of RALA activation. {ECO:0000269|PubMed:15143197, ECO:0000269|PubMed:19306925}.
Subcellular locationCell surface {ECO:0000269|PubMed:19306925}. Cell membrane {ECO:0000269|PubMed:19306925};
Multi-pass membrane protein {ECO:0000269|PubMed:19306925}. Note=Prior to LPA treatment found predominantly at the cell surface but in the presence of LPA colocalizes with RALA in the endocytic vesicles.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q9HBW0
Gene Ontology
(Biological Process)
Complete annatation
activation of phospholipase C activity [GO:0007202];
G-protein coupled receptor signaling pathway [GO:0007186];
positive regulation of cytosolic calcium ion concentration [GO:0007204]
Gene Ontology
(Molecular Function)
Complete annatation
G-protein coupled receptor activity [GO:0004930];
lipid binding [GO:0008289];
lysophosphatidic acid receptor activity [GO:0070915]
Gene Ontology
(Cellular Component)
Complete annatation
cell surface [GO:0009986];
integral component of plasma membrane [GO:0005887];
plasma membrane [GO:0005886]
Protein-protein interaction114611
Phylogenetic treeQ9HBW0
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
      Yes - Two siRNA pools inhibit HIV replication and inhibition of Tat-mediated transactivation of the HIV LTR is not observed
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-1.982511967679061.42936437130814e-081.63331158486401e-07
AZA vs. DISU0.3990866968980930.11665880579490.668893544657176
AZA vs. IL7-0.1408847646421040.563592417301640.999311006273513
AZA vs. SAHA-0.5960082213908430.02077015164610580.158125891875454
DISU vs. CD32.368715953609226.40257957762458e-101.34886303726613e-08
DISU vs. IL7-0.5499119055509330.03001558344637870.223891598443423
DISU vs. SAHA-0.9917300081961010.000813366587640640.0178952523245724
DMSO vs. AZA0.03955260497850170.8460273473335031
DMSO vs. CD32.012591782810142.25679619436647e-092.7374101987223e-08
DMSO vs. DISU-0.3607629634353740.1411793366885410.633737983463291
DMSO vs. IL7-0.1731715662264970.4129143492529350.849123958050597
DMSO vs. SAHA-0.640685395422630.007106624865236610.07159354501603
HIV vs. Mock in Activation0.3091409709926540.6252706466251910.999983755607037
HIV vs. Mock in Latency0.03708938494336250.823728568474310.999834320637052
IL7 vs. CD31.845612102075471.12998336465608e-071.35715053828376e-06
SAHA vs. CD31.363825564337350.0002110122923206780.000923063931864331
SAHA vs. IL7-0.4569442704107270.08282702831939810.256227561786718
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) TRUE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.12339 0.458584
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
206722_s_at 1.41 No downregulated in CD8+ cells

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
4P0C X-ray 1.3Å A=347-351.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
HIV-1 virus replication enhanced by expression of human gene 18976975

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04015 Rap1 signaling pathway - Homo sapiens (human)
hsa04072 Phospholipase D signaling pathway - Homo sapiens (human)
hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human)
hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
hsa05200 Pathways in cancer - Homo sapiens (human)