Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0001636
UniProt IDP20700
Primary gene name(s)LMNB1
Synonym gene name(s)LMN2, LMNB
Protein nameLamin-B1
Protein functionLamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin.
Subcellular locationNucleus inner membrane;
Lipid-anchor;
Nucleoplasmic side.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P20700
Gene Ontology
(Biological Process)
Complete annatation
unknown
Gene Ontology
(Molecular Function)
Complete annatation
structural molecule activity [GO:0005198]
Gene Ontology
(Cellular Component)
Complete annatation
lamin filament [GO:0005638];
membrane [GO:0016020];
nuclear envelope [GO:0005635];
nuclear inner membrane [GO:0005637];
nuclear matrix [GO:0016363];
nuclear membrane [GO:0031965];
nucleoplasm [GO:0005654]
Protein-protein interaction110187
Phylogenetic treeP20700
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
      unknown
Brass et al., Science, 2008
      unknown
Smith et al., J. Immunol, 2010
      unknown
Interferon-stimulated
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model


DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD31.412339510426570.0002405727862456740.0010437285648517
AZA vs. DISU-0.0522672852150580.836744576506930.986167923867511
AZA vs. IL70.4300984375358080.02673427490315840.525379042523216
AZA vs. SAHA-0.5259353503877890.03238836499452760.208019690638052
DISU vs. CD3-1.476054237722390.0001344659090584120.000733335424437954
DISU vs. IL70.4725937337174890.06230845988039420.329001762766005
DISU vs. SAHA-0.4720730956279080.1068321787319140.419725694908414
DMSO vs. AZA-0.05395088294325170.749566107194091
DMSO vs. CD3-1.474230631629780.0002360034489714560.00096509010823968
DMSO vs. DISU-0.00277399004386010.9909534076838140.99806609310612
DMSO vs. IL70.4907935354312940.007970132385151650.18599031843059
DMSO vs. SAHA-0.4788960787739690.04367536277196560.23316733699479
HIV vs. Mock in Activation-0.05497100207951830.9494731028932450.999983755607037
HIV vs. Mock in Latency0.2109242360763160.3145949366589520.999834320637052
IL7 vs. CD3-0.9754605524865990.01539213688628990.0424452395329396
SAHA vs. CD3-1.962106759346825.89801240846732e-075.08484250546925e-06
SAHA vs. IL7-0.9581192965199720.0001046784619572750.00202395975713659
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
0.5316 0.02167

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
2 0.01128812 1.3 0.397631207 1.3 0.516814023
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) FALSE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.633676 0.000305467
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
0.032 0.002

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
1.044 1.005 1.097 1.13 1.051
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
203276_at 1.53 Yes upregulated in CD4+ cells
203276_at 3.19 Yes upregulated in CD8+ cells

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
2KPW NMR - A=439-549.
3JT0 X-ray 2.3Å A/B=426-558.
3TYY X-ray 2.4Å A/B=311-388.
3UMN X-ray 2.0Å A/B/C=428-550.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Vpr co-localizes with 9436978
11691994
Vpr downregulates 23874603
Tat binds 2406262
2544227
19454010

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04210 Apoptosis - Homo sapiens (human)
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