Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0001617
UniProt IDP13796
Primary gene name(s)LCP1
Synonym gene name(s)PLS2
Protein namePlastin-2
Protein functionActin-binding protein. Plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28. Modulates the cell surface expression of IL2RA/CD25 and CD69. {ECO:0000269|PubMed:16636079, ECO:0000269|PubMed:17294403}.
Subcellular locationCytoplasm, cytoskeleton {ECO:0000269|PubMed:16636079}. Cell junction {ECO:0000269|PubMed:17294403}. Cell projection {ECO:0000269|PubMed:16636079}. Cell projection, ruffle membrane {ECO:0000250|UniProtKB:Q61233, ECO:0000269|PubMed:16636079};
Peripheral membrane protein {ECO:0000250|UniProtKB:Q61233};
Cytoplasmic side {ECO:0000250|UniProtKB:Q61233}. Note=Relocalizes to the immunological synapse between peripheral blood T-lymphocytes and antibody-presenting cells in response to costimulation through TCR/CD3 and CD2 or CD28, PubMed:17294403. Associated with the actin cytoskeleton at membrane ruffles. Relocalizes to actin-rich cell projections upon serine phosphorylation, PubMed:16636079. {ECO:0000250|UniProtKB:Q61233, ECO:0000269|PubMed:16636079, ECO:0000269|PubMed:17294403}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P13796
Gene Ontology
(Biological Process)
Complete annatation
actin crosslink formation [GO:0051764];
actin filament bundle assembly [GO:0051017];
actin filament network formation [GO:0051639];
animal organ regeneration [GO:0031100];
cell migration [GO:0016477];
extracellular matrix disassembly [GO:0022617];
positive regulation of podosome assembly [GO:0071803];
protein kinase A signaling [GO:0010737];
regulation of intracellular protein transport [GO:0033157];
T cell activation involved in immune response [GO:0002286]
Gene Ontology
(Molecular Function)
Complete annatation
actin binding [GO:0003779];
actin filament binding [GO:0051015];
calcium ion binding [GO:0005509];
GTPase binding [GO:0051020]
Gene Ontology
(Cellular Component)
Complete annatation
actin cytoskeleton [GO:0015629];
actin filament [GO:0005884];
actin filament bundle [GO:0032432];
cytoplasm [GO:0005737];
cytosol [GO:0005829];
extracellular exosome [GO:0070062];
extracellular space [GO:0005615];
filopodium [GO:0030175];
focal adhesion [GO:0005925];
phagocytic cup [GO:0001891];
plasma membrane [GO:0005886];
podosome [GO:0002102];
ruffle [GO:0001726];
ruffle membrane [GO:0032587]
Protein-protein interaction110128
Phylogenetic treeP13796
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-0.6274480133139090.09715581614465050.171890182055661
AZA vs. DISU-0.2763172245580070.2739482174349540.846086444137247
AZA vs. IL70.2301528052012240.2295637836837980.989557594204189
AZA vs. SAHA0.05441213383080120.823367090810210.956625255596125
DISU vs. CD30.3387318774573020.3810797943580160.515331194056942
DISU vs. IL70.4974890119984330.04878759711676170.291391848864969
DISU vs. SAHA0.332105035221370.2538218892810810.632393733403071
DMSO vs. AZA-0.002424644626259260.9883831726644341
DMSO vs. CD30.6132329493347160.1054455055786560.17842710788975
DMSO vs. DISU0.2719519703838490.2645454566117910.78420724923707
DMSO vs. IL70.2398593592823290.1804370049402970.690678506545486
DMSO vs. SAHA0.05021534744513340.8313662454096270.954164160556043
HIV vs. Mock in Activation0.07237741984634690.9337567398989850.999983755607037
HIV vs. Mock in Latency-0.02804722541365080.8646179283848550.999834320637052
IL7 vs. CD30.8654190670307760.02720794944513070.067164333767844
SAHA vs. CD30.6573265961792580.1091524976963430.187008656239642
SAHA vs. IL7-0.1787507881804860.4642993095675860.699744830276123
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) FALSE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.152293 0.378554
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
1.054 1.047 1.212 1.303 1.184
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
2D85 NMR - A=517-627.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Envelope surface glycoprotein gp160; precursor cleaved by 9923600
Envelope surface glycoprotein gp120 downregulates 17676665
retropepsin cleaves 12119179

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
not found