Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0001611
UniProt IDQ9NRM7
Primary gene name(s)LATS2
Synonym gene name(s)KPM
Protein nameSerine/threonine-protein kinase LATS2
Protein functionNegative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity. Negative regulator of the androgen receptor. Phosphorylates SNAI1 in the nucleus leading to its nuclear retention and stabilization, which enhances its epithelial-mesenchymal transition and tumor cell invasion/migration activities. This tumor-promoting activity is independent of its effects upon YAP1 or WWTR1/TAZ. {ECO:0000269|PubMed:10871863, ECO:0000269|PubMed:12853976, ECO:0000269|PubMed:15131260, ECO:0000269|PubMed:18158288, ECO:0000269|PubMed:21952048}.
Subcellular locationCytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Cytoplasm, cytoskeleton, spindle pole. Nucleus. Note=Colocalizes with AURKA at the centrosomes during interphase, early prophase and cytokinesis. Migrates to the spindle poles during mitosis, and to the midbody during cytokinesis. Translocates to the nucleus upon mitotic stress by nocodazole treatment.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q9NRM7
Gene Ontology
(Biological Process)
Complete annatation
cell division [GO:0051301];
cellular protein localization [GO:0034613];
G1/S transition of mitotic cell cycle [GO:0000082];
hippo signaling [GO:0035329];
hormone-mediated signaling pathway [GO:0009755];
inner cell mass cell fate commitment [GO:0001827];
inner cell mass cellular morphogenesis [GO:0001828];
intracellular signal transduction [GO:0035556];
keratinocyte differentiation [GO:0030216];
mitotic nuclear division [GO:0007067];
negative regulation of canonical Wnt signaling pathway [GO:0090090];
negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736];
peptidyl-serine phosphorylation [GO:0018105];
positive regulation of apoptotic process [GO:0043065];
protein phosphorylation [GO:0006468];
regulation of organ growth [GO:0046620]
Gene Ontology
(Molecular Function)
Complete annatation
ATP binding [GO:0005524];
metal ion binding [GO:0046872];
protein serine/threonine kinase activity [GO:0004674]
Gene Ontology
(Cellular Component)
Complete annatation
cytoplasm [GO:0005737];
cytosol [GO:0005829];
microtubule organizing center [GO:0005815];
nucleus [GO:0005634];
spindle pole [GO:0000922]
Protein-protein interaction117727
Phylogenetic treeQ9NRM7
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
      unknown
Brass et al., Science, 2008
      unknown
Smith et al., J. Immunol, 2010
      unknown
Interferon-stimulated
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model


DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-0.03259875886968140.9224052946565690.950215411821002
AZA vs. DISU0.2907013455561020.2634793056014780.841555127581721
AZA vs. IL7-0.1103887205804130.5884285100649230.999311006273513
AZA vs. SAHA0.5477760143437410.02988424597505970.19923711801329
DISU vs. CD30.3106668861059220.3980451235916170.531738053263031
DISU vs. IL7-0.4110893066323830.1127988547646170.440529206107926
DISU vs. SAHA0.2594918120550130.3827378169348850.749347979597725
DMSO vs. AZA-0.05936713575741570.7421393657592751
DMSO vs. CD3-0.03799757000430470.9073414635041640.936427150287527
DMSO vs. DISU-0.35188932487070.160620587820110.66717219303376
DMSO vs. IL7-0.04427161957654940.817018746526420.962956477091318
DMSO vs. SAHA0.601267192797730.01364341215766320.110171065540987
HIV vs. Mock in Activation0.4646413233914460.4614337133152090.999983755607037
HIV vs. Mock in Latency0.05482919487471530.7528622520408130.999834320637052
IL7 vs. CD3-0.07134531329165340.8270966580553520.887983924215343
SAHA vs. CD30.556680375764160.1258905410155590.209516339382052
SAHA vs. IL70.6564157201338630.009830752032844890.0616685923312203
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) TRUE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.584977 0.000305467
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
4ZRI X-ray 2.7Å C/D=68-99.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04390 Hippo signaling pathway - Homo sapiens (human)
hsa04392 Hippo signaling pathway -multiple species - Homo sapiens (human)
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