Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0001603
UniProt IDQ6PKG0
Primary gene name(s)LARP1
Synonym gene name(s)KIAA0731, LARP
Protein nameLa-related protein 1
Protein functionRNA-binding protein that promotes translation of specific classes of mRNAs downstream of the mTORC1 complex. Associates with the mRNA 5'cap in an MTOR-dependent manner and associates with mRNAs containing a 5' terminal oligopyrimidine, 5'TOP motif, which is present in mRNAs encoding for ribosomal proteins and several components of the translation machinery. Associates with actively translating ribosomes via interaction with PABPC1/PABP and stimulates translation of mRNAs containing a 5'TOP, thereby regulating cell growth and proliferation. Positively regulates the replication of dengue virus, DENV, PubMed:26735137. {ECO:0000269|PubMed:20430826, ECO:0000269|PubMed:23711370, ECO:0000269|PubMed:24532714, ECO:0000269|PubMed:26735137}.
Subcellular locationCytoplasm {ECO:0000269|PubMed:20430826, ECO:0000269|PubMed:24532714}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q6PKG0
Gene Ontology
(Biological Process)
Complete annatation
cell proliferation [GO:0008283];
positive regulation of macroautophagy [GO:0016239];
positive regulation of viral genome replication [GO:0045070];
TOR signaling [GO:0031929];
translational initiation [GO:0006413]
Gene Ontology
(Molecular Function)
Complete annatation
eukaryotic initiation factor 4E binding [GO:0008190];
mRNA 3'-UTR binding [GO:0003730];
mRNA 5'-UTR binding [GO:0048027];
poly(A RNA binding [GO:0044822];
RNA cap binding [GO:0000339];
translation activator activity [GO:0008494];
translation initiation factor binding [GO:0031369]
Gene Ontology
(Cellular Component)
Complete annatation
cytoplasm [GO:0005737];
membrane [GO:0016020];
nucleoplasm [GO:0005654]
Protein-protein interaction116947
Phylogenetic treeQ6PKG0
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
      unknown
Brass et al., Science, 2008
      unknown
Smith et al., J. Immunol, 2010
      unknown
Interferon-stimulated
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model


DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD30.8975274202150140.006801661521214420.0188169314331395
AZA vs. DISU0.0527456036246330.8344689662365490.986138307819745
AZA vs. IL70.250980101747820.1907204390906810.954510558301023
AZA vs. SAHA0.04727791246283880.8460365398630440.963474674433101
DISU vs. CD3-0.8579008399867270.01937665014599870.0500816962657007
DISU vs. IL70.189377705482760.4513565009150170.797079038530056
DISU vs. SAHA-0.003716338266320920.9898074061239890.999274089415579
DMSO vs. AZA0.01506302780085520.9281195785508011
DMSO vs. CD3-0.8947295563911480.005815245042463450.015621730842495
DMSO vs. DISU-0.03983033620033510.8700556446042980.985754420456971
DMSO vs. IL70.243452921004670.1746833738966140.684776955532741
DMSO vs. SAHA0.02581775083157030.9126022331128790.979403400357616
HIV vs. Mock in Activation0.2870515300829650.6443909967656960.999983755607037
HIV vs. Mock in Latency-0.0225076782410450.8911270756756320.999834320637052
IL7 vs. CD3-0.639238196951950.04897647480960240.107943033309714
SAHA vs. CD3-0.8750236335923480.01473583286618770.035582278688263
SAHA vs. IL7-0.2072446721226550.3938685202871170.641787274327964
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) FALSE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.51825 0.000580925
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
0.938 0.915 0.736 0.651 0.814
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
4ZC4 X-ray 1.8Å A/B/C/D=873-1023.
5C0V X-ray 2.2Å A/B/C/D=873-1023.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Pr55(Gag) incorporates 25631074
Pr55(Gag) interacts with 25010285

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
not found
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