Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0001562
UniProt IDQ9Y496
Primary gene name(s)KIF3A
Synonym gene name(s)KIF3
Protein nameKinesin-like protein KIF3A
Protein functionMicrotubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro. Plays a role in primary cilia formation. Plays a role in centriole cohesion and subdistal appendage organization and function. Regulates the formation of the subdistal appendage via recruitement of DCTN1 to the centriole. Also required for ciliary basal feet formation and microtubule anchoring to mother centriole. {ECO:0000250|UniProtKB:P28741}.
Subcellular locationCytoplasm, cytoskeleton {ECO:0000305}. Cell projection, cilium {ECO:0000250|UniProtKB:P28741}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:23386061}. Note=Localizes to the subdistal appendage region of the centriole. {ECO:0000269|PubMed:23386061}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q9Y496
Gene Ontology
(Biological Process)
Complete annatation
antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886];
centriole-centriole cohesion [GO:0010457];
cilium assembly [GO:0060271];
microtubule anchoring at centrosome [GO:0034454];
microtubule-based movement [GO:0007018];
neurogenesis [GO:0022008];
organelle organization [GO:0006996];
plus-end-directed vesicle transport along microtubule [GO:0072383];
retrograde vesicle-mediated transport, Golgi to ER [GO:0006890]
Gene Ontology
(Molecular Function)
Complete annatation
ATP binding [GO:0005524];
ATP-dependent microtubule motor activity, plus-end-directed [GO:0008574];
spectrin binding [GO:0030507]
Gene Ontology
(Cellular Component)
Complete annatation
centrosome [GO:0005813];
ciliary tip [GO:0097542];
cytosol [GO:0005829];
extracellular exosome [GO:0070062];
kinesin II complex [GO:0016939];
microtubule [GO:0005874];
microtubule cytoskeleton [GO:0015630];
primary cilium [GO:0072372]
Protein-protein interaction116300
Phylogenetic treeQ9Y496
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
      Negatively associated
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD32.202820792195021.63907887262837e-102.76333297184059e-09
AZA vs. DISU0.2410234723866470.3449251529846240.883324902695907
AZA vs. IL70.1519030937158020.4327436569342030.999311006273513
AZA vs. SAHA0.6225346243537840.03047929366557430.201334300050336
DISU vs. CD3-1.974375580594431.44806908353168e-071.703996359497e-06
DISU vs. IL7-0.09763904659086870.7010994417728070.923627902186933
DISU vs. SAHA0.3817581819693950.210590141006320.584494293758056
DMSO vs. AZA0.01151842423040830.9457407450053261
DMSO vs. CD3-2.200337250398956.24230667156667e-111.0188553630244e-09
DMSO vs. DISU-0.2305687675489940.3489844175012340.842312150921815
DMSO vs. IL70.1471480266347890.4165503449563970.851351608478654
DMSO vs. SAHA0.602396320226310.0279325124119160.176655851682747
HIV vs. Mock in Activation0.02605018474166480.966626752076330.999983755607037
HIV vs. Mock in Latency0.1097179385345080.5093918882455220.999834320637052
IL7 vs. CD3-2.041633133388911.32966293531211e-092.34959078827192e-08
SAHA vs. CD3-1.606229888861851.61574700059397e-059.53752733997302e-05
SAHA vs. IL70.4659022568113780.1163602143449010.314452110260853
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change -1.412150421
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) FALSE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.0799072 0.686219
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
0.882 1.095 0.928 1.093 1.167
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Pr55(Gag) modulated by 19934039
HIV-1 virus replication enhanced by expression of human gene 18854154

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04340 Hedgehog signaling pathway - Homo sapiens (human)