Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0001558
UniProt IDQ14807
Primary gene name(s)KIF22
Synonym gene name(s)KID, KNSL4
Protein nameKinesin-like protein KIF22
Protein functionKinesin family member that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Binds to microtubules and to DNA, By similarity. Plays a role in congression of laterally attached chromosomes in NDC80-depleted cells, PubMed:25743205. {ECO:0000250|UniProtKB:Q9I869, ECO:0000269|PubMed:25743205}.
Subcellular locationNucleus {ECO:0000269|PubMed:8599929}. Cytoplasm, cytoskeleton {ECO:0000305}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q14807
Gene Ontology
(Biological Process)
Complete annatation
antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886];
DNA repair [GO:0006281];
metaphase plate congression [GO:0051310];
microtubule-based movement [GO:0007018];
mitotic metaphase plate congression [GO:0007080];
mitotic nuclear division [GO:0007067];
retrograde vesicle-mediated transport, Golgi to ER [GO:0006890];
sister chromatid cohesion [GO:0007062]
Gene Ontology
(Molecular Function)
Complete annatation
ATPase activity [GO:0016887];
ATP binding [GO:0005524];
DNA binding [GO:0003677];
microtubule motor activity [GO:0003777]
Gene Ontology
(Cellular Component)
Complete annatation
chromatin [GO:0000785];
cytoplasm [GO:0005737];
cytosol [GO:0005829];
focal adhesion [GO:0005925];
kinesin complex [GO:0005871];
kinetochore [GO:0000776];
microtubule [GO:0005874];
mitotic spindle [GO:0072686];
nucleus [GO:0005634]
Protein-protein interaction110033
Phylogenetic treeQ14807
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-0.1418262541361530.6663634207426680.758452611194192
AZA vs. DISU-0.02890873082055130.9097652233473170.994271142470137
AZA vs. IL7-0.2334512798477440.225626963985490.989265982093417
AZA vs. SAHA-0.2773387825288870.2564258598002970.628718837122588
DISU vs. CD30.1007895391244270.7808359935990650.849154951583112
DISU vs. IL7-0.2140449388596390.4142862242305060.77296317295356
DISU vs. SAHA-0.2464138717352460.4046301627842730.762973696343782
DMSO vs. AZA0.01219176715523230.9420489202726711
DMSO vs. CD30.1403061493877960.6621672199801330.750097689224806
DMSO vs. DISU0.03874869474949930.8772346899830920.987443803738299
DMSO vs. IL7-0.2381694977064950.186234603101760.69872738719737
DMSO vs. SAHA-0.2945531645531920.2123618893464740.554872752139512
HIV vs. Mock in Activation0.005768906260642870.9926178546325450.999983755607037
HIV vs. Mock in Latency0.1532275668596260.3535424226796910.999834320637052
IL7 vs. CD3-0.08524171614350170.7909852508076850.862186678025816
SAHA vs. CD3-0.1590652183995840.6556418723533080.74356413026198
SAHA vs. IL7-0.04667518983640860.8485360870960340.936165774492104
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
1.7 0.005564487 1.4 0.015428855 1.4 0.049958841
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) FALSE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.446431 0.840242
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
1.071 1.446 1.458 1.2 1.245
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
2EDU NMR - A=570-660.
3BFN X-ray 2.3Å A=40-400.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Rev binds 12805422

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
not found