Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0001512
UniProt IDQ92945
Primary gene name(s)KHSRP
Synonym gene name(s)FUBP2
Protein nameFar upstream element-binding protein 2
Protein functionBinds to the dendritic targeting element and may play a role in mRNA trafficking, By similarity. Part of a ternary complex that binds to the downstream control sequence, DCS of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element, FUSE. May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements, AREs in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs. {ECO:0000250, ECO:0000269|PubMed:11003644, ECO:0000269|PubMed:8940189, ECO:0000269|PubMed:9136930}.
Subcellular locationNucleus {ECO:0000269|PubMed:19198587}. Cytoplasm {ECO:0000269|PubMed:19198587}. Note=A small proportion is also found in the cytoplasm of neuronal cell bodies and dendrites. {ECO:0000250}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q92945
Gene Ontology
(Biological Process)
Complete annatation
3'-UTR-mediated mRNA destabilization [GO:0061158];
cellular response to cytokine stimulus [GO:0071345];
mRNA catabolic process [GO:0006402];
mRNA processing [GO:0006397];
mRNA transport [GO:0051028];
negative regulation of nitric oxide biosynthetic process [GO:0045019];
positive regulation of mRNA catabolic process [GO:0061014];
regulation of miRNA metabolic process [GO:2000628];
regulation of mRNA stability [GO:0043488];
regulation of transcription, DNA-templated [GO:0006355];
RNA splicing [GO:0008380];
RNA splicing, via transesterification reactions [GO:0000375];
transcription, DNA-templated [GO:0006351]
Gene Ontology
(Molecular Function)
Complete annatation
DNA binding [GO:0003677];
mRNA 3'-UTR binding [GO:0003730];
poly(A RNA binding [GO:0044822]
Gene Ontology
(Cellular Component)
Complete annatation
cytoplasmic stress granule [GO:0010494];
cytosol [GO:0005829];
dendrite [GO:0030425];
membrane [GO:0016020];
neuronal cell body [GO:0043025];
nucleoplasm [GO:0005654]
Protein-protein interaction114139
Phylogenetic treeQ92945
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD31.266574601245810.0001368500836042010.000637590250411906
AZA vs. DISU0.1828012089118020.4699999141987640.926405371176645
AZA vs. IL70.113171950098570.5562123870221480.999311006273513
AZA vs. SAHA0.03961473252548650.8710733600788710.970578948192473
DISU vs. CD3-1.096597468708520.002800220772052770.00999625232474244
DISU vs. IL7-0.07899573990532350.753610911998160.941323479325969
DISU vs. SAHA-0.140764374899450.6300658488109540.883204259744771
DMSO vs. AZA-0.02493456453559870.8817200487397281
DMSO vs. CD3-1.303983625621285.91404688753405e-050.000281730825083218
DMSO vs. DISU-0.2098861310295170.3897042494898380.86028854108019
DMSO vs. IL70.1455941089416930.4181980522388530.852614705558083
DMSO vs. SAHA0.05932300285441310.801513087114910.944454878132789
HIV vs. Mock in Activation0.2930571753423320.6374665359697760.999983755607037
HIV vs. Mock in Latency-0.001231280792039560.9940528529932280.999834320637052
IL7 vs. CD3-1.147327363142050.0004222391442710860.00202301672650924
SAHA vs. CD3-1.250401866847130.0004801765370134880.00189093762640038
SAHA vs. IL7-0.07585884086409450.7560633518545740.890499079776306
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) FALSE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.185233 0.193149
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
1.016 0.917 0.851 0.839 0.943
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
2HH2 NMR - A=424-525.
2HH3 NMR - A=318-418.
2JVZ NMR - A=233-396.
2OPU NMR - A=130-218.
2OPV NMR - A=221-305.
4B8T NMR - A=317-418.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Envelope surface glycoprotein gp120 complexes with 23125841
Gag-Pol complexes with 23125841
Vpr upregulates 23874603
Pr55(Gag) complexes with 23125841
Nef complexes with 23125841

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
not found