Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0001499
UniProt IDQ9NR82
Primary gene name(s)KCNQ5
Synonym gene name(s)unknown
Protein namePotassium voltage-gated channel subfamily KQT member 5
Protein functionProbably important in the regulation of neuronal excitability. Associates with KCNQ3 to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons. May contribute, with other potassium channels, to the molecular diversity of a heterogeneous population of M-channels, varying in kinetic and pharmacological properties, which underlie this physiologically important current. Insensitive to tetraethylammonium, but inhibited by barium, linopirdine and XE991. Activated by niflumic acid and the anticonvulsant retigabine. Muscarine suppresses KCNQ5 current in Xenopus oocytes in which cloned KCNQ5 channels were coexpressed with M(1 muscarinic receptors.
Subcellular locationMembrane;
Multi-pass membrane protein.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q9NR82
Gene Ontology
(Biological Process)
Complete annatation
chemical synaptic transmission [GO:0007268];
protein complex assembly [GO:0006461]
Gene Ontology
(Molecular Function)
Complete annatation
delayed rectifier potassium channel activity [GO:0005251];
inward rectifier potassium channel activity [GO:0005242];
voltage-gated potassium channel activity [GO:0005249]
Gene Ontology
(Cellular Component)
Complete annatation
clathrin coat [GO:0030118];
plasma membrane [GO:0005886];
voltage-gated potassium channel complex [GO:0008076]
Protein-protein interaction121149
Phylogenetic treeQ9NR82
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD31.059234988691980.00559723271984980.0159413249345382
AZA vs. DISU-0.6514749375365750.03804788114724070.450959390481316
AZA vs. IL70.3489700450361360.2374156174748830.990920320206469
AZA vs. SAHA-0.7830736426079540.1788320129613460.539886509351535
DISU vs. CD3-1.72228107528676.7805211059091e-050.000404150158760276
DISU vs. IL70.9934582136721820.003484736720334450.0603479796098513
DISU vs. SAHA-0.1317883908407420.8225905943005680.954457236048875
DMSO vs. AZA-0.02222760831651380.9272055982063841
DMSO vs. CD3-1.097689533868460.002220846181668290.00682796892384343
DMSO vs. DISU0.6261056918712830.03046411314260680.351971296434249
DMSO vs. IL70.3792902709789510.1620611545564320.66823629784962
DMSO vs. SAHA-0.7679216298566990.1758790981463260.507014898271478
HIV vs. Mock in Activation-0.2623728710953360.717569055232160.999983755607037
HIV vs. Mock in Latency0.1212614080451140.4907745497527090.999834320637052
IL7 vs. CD3-0.7005233520325510.08447796696765540.166145145629367
SAHA vs. CD3-1.86758356600030.006888779753386640.0187423561804544
SAHA vs. IL7-1.138045124099370.05463888489703070.195620097190717
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) FALSE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.0896309 0.623038
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

Drugbank ID Drug Name Drug Status Pharmacological Action Drug Action
DB04953 Ezogabine approved unknown unknown
DB06089 ICA-105665 investigational unknown unknown

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04725 Cholinergic synapse - Homo sapiens (human)