Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0001498
UniProt IDQ9Y257
Primary gene name(s)KCNK6
Synonym gene name(s)TOSS, TWIK2
Protein namePotassium channel subfamily K member 6
Protein functionExhibits outward rectification in a physiological K(+ gradient and mild inward rectification in symmetrical K(+ conditions.
Subcellular locationMembrane {ECO:0000305};
Multi-pass membrane protein {ECO:0000305}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q9Y257
Gene Ontology
(Biological Process)
Complete annatation
cardiac conduction [GO:0061337];
negative regulation of systemic arterial blood pressure [GO:0003085];
potassium ion transport [GO:0006813];
regulation of resting membrane potential [GO:0060075];
stabilization of membrane potential [GO:0030322]
Gene Ontology
(Molecular Function)
Complete annatation
inward rectifier potassium channel activity [GO:0005242];
potassium channel activity [GO:0005267];
potassium ion leak channel activity [GO:0022841]
Gene Ontology
(Cellular Component)
Complete annatation
plasma membrane [GO:0005886];
voltage-gated potassium channel complex [GO:0008076]
Protein-protein interactionunknown
Phylogenetic treeQ9Y257
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD30.6166456834312580.06183373839928970.11867542406139
AZA vs. DISU-0.3335024527145550.1929587766991990.781267955939758
AZA vs. IL70.001782193156118930.9927477781930820.999311006273513
AZA vs. SAHA-0.6757232947614670.006676763359757980.0746705487007379
DISU vs. CD3-0.9614695547393770.008811188353135660.0260328994972887
DISU vs. IL70.3259115285251150.201009218547550.577293573938715
DISU vs. SAHA-0.3405933270484280.2483921483031380.626844954299496
DMSO vs. AZA-0.02519844756997640.8836450021660151
DMSO vs. CD3-0.654075617638790.04256529138390260.0839753143165343
DMSO vs. DISU0.3063219031757190.2149758212617350.726712791927848
DMSO vs. IL70.03447501302563940.851009986460750.966863745921932
DMSO vs. SAHA-0.6560187583391730.006394168154875260.066459660870431
HIV vs. Mock in Activation-0.006376358187030960.9918362618547710.999983755607037
HIV vs. Mock in Latency0.001059939175736580.9949902319295010.999834320637052
IL7 vs. CD3-0.6082885293985580.06037339502446320.127971900323968
SAHA vs. CD3-1.316091413475340.0002731453159200430.00115821606947525
SAHA vs. IL7-0.6802815617722660.006159408275884240.0448033506366621
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) TRUE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.380807 0.00710819
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

Drugbank ID Drug Name Drug Status Pharmacological Action Drug Action
DB00308 Ibutilide approved unknown inhibitor
DB00908 Quinidine approved unknown inhibitor

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
retropepsin cleaves 22944692

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
not found