Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0001496
UniProt IDQ9NS61
Primary gene name(s)KCNIP2
Synonym gene name(s)KCHIP2
Protein nameKv channel-interacting protein 2
Protein functionRegulatory subunit of Kv4/D, Shal-type voltage-gated rapidly inactivating A-type potassium channels. Modulates channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND2/Kv4.2 and KCND3/Kv4.3 currents. Involved in KCND2 and KCND3 trafficking to the cell surface. May be required for the expression of I(To currents in the heart, By similarity. {ECO:0000250|UniProtKB:Q9JJ69, ECO:0000269|PubMed:10676964, ECO:0000269|PubMed:11287421, ECO:0000269|PubMed:11684073, ECO:0000269|PubMed:12297301, ECO:0000269|PubMed:12829703, ECO:0000269|PubMed:14623880}.
Subcellular locationIsoform 1: Cell membrane {ECO:0000250|UniProtKB:Q9JM59};
Lipid-anchor {ECO:0000250|UniProtKB:Q9JM59}. Note=Detected on lipid rafts, By similarity. {ECO:0000250|UniProtKB:Q9JM59}.;
SUBCELLULAR LOCATION: Isoform 2: Cell membrane {ECO:0000250|UniProtKB:Q9JM59};
Lipid-anchor {ECO:0000250|UniProtKB:Q9JM59}.;
SUBCELLULAR LOCATION: Isoform 6: Cell membrane {ECO:0000250|UniProtKB:Q9JM59};
Lipid-anchor {ECO:0000250|UniProtKB:Q9JM59}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q9NS61
Gene Ontology
(Biological Process)
Complete annatation
cardiac conduction [GO:0061337];
chemical synaptic transmission [GO:0007268];
clustering of voltage-gated potassium channels [GO:0045163];
detection of calcium ion [GO:0005513];
membrane repolarization [GO:0086009];
membrane repolarization during cardiac muscle cell action potential [GO:0086013];
muscle contraction [GO:0006936];
potassium ion export [GO:0071435];
potassium ion export across plasma membrane [GO:0097623];
potassium ion transmembrane transport [GO:0071805];
potassium ion transport [GO:0006813];
regulation of cation channel activity [GO:2001257];
regulation of heart contraction [GO:0008016];
regulation of potassium ion transmembrane transport [GO:1901379];
signal transduction [GO:0007165]
Gene Ontology
(Molecular Function)
Complete annatation
A-type, transient outward potassium channel activity [GO:0005250];
calcium ion binding [GO:0005509];
ER retention sequence binding [GO:0046923];
identical protein binding [GO:0042802];
ion channel binding [GO:0044325];
potassium channel regulator activity [GO:0015459];
protein N-terminus binding [GO:0047485]
Gene Ontology
(Cellular Component)
Complete annatation
cytoplasm [GO:0005737];
plasma membrane [GO:0005886];
voltage-gated potassium channel complex [GO:0008076]
Protein-protein interaction119043
Phylogenetic treeQ9NS61
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-1.299142306447970.001973331254828010.00654534521847884
AZA vs. DISU-0.6566500331210280.01527300547372090.301580020967485
AZA vs. IL70.08827550530640390.6748325129212960.999311006273513
AZA vs. SAHA0.4633481249930030.07198892289804530.332158256432548
DISU vs. CD30.628219468020670.1317226385517150.23142125832452
DISU vs. IL70.7342205874143060.006250310123723240.0862062443871251
DISU vs. SAHA1.121914335381590.0002573850656238940.00768128777033209
DMSO vs. AZA0.1251527703474510.5069657765530051
DMSO vs. CD31.413271620607310.0008024622053196540.00282191716226438
DMSO vs. DISU0.7801515338687250.002759322539347850.113910080467851
DMSO vs. IL7-0.02974472675850860.8797320189578840.973639653899924
DMSO vs. SAHA0.3322266512610170.1795118960122660.512196854373507
HIV vs. Mock in Activation0.4855919805244820.5665891929626060.999983755607037
HIV vs. Mock in Latency-0.03795534038095340.8826214685078660.999834320637052
IL7 vs. CD31.389665824116140.0009092654796487580.00390911539496455
SAHA vs. CD31.736954341735993.69710243772747e-050.000199339297805199
SAHA vs. IL70.372525524312990.144616122662690.358636241082101
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) TRUE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.0180699 0.976135
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
not found